Antenatal dexamethasone and decreased birth weight

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

Objective: To test the hypothesis that antenatal dexamethasone treatment to promote fetal lung maturation results in decreased birth weight corrected for gestational age. Methods: The birth weights of all dexamethasone-treated, singleton, live-born infants delivered at our hospital were compared with our overall obstetric population; a group of untreated infants frequency matched approximately 3:1 according to maternal race, infant sex, and gestational age at delivery; and an historical cohort of infants with an indication for dexamethasone but delivered in the 12 months before the introduction of corticosteroid therapy at our hospital. Results: Dexamethasone-treated infants (n = 961), when compared with either the overall population (n = 122,629) or matched controls (n = 2808), had significantly lower birth weights after adjustment for week of gestation (P < .001). Compared with the historical cohort of infants, the average birth weight of dexamethasone-treated infants was smaller by 12 g at 24-26 weeks, 63 g at 27-29 weeks, 161 g at 30-32 weeks, and 80 g at 33-34 weeks' gestation. Conclusion: Antenatal dexamethasone administered to promote fetal maturation is associated with diminished birth weight.

Original languageEnglish (US)
Pages (from-to)485-490
Number of pages6
JournalObstetrics and Gynecology
Volume97
Issue number4
DOIs
StatePublished - 2001

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Birth Weight
Dexamethasone
Gestational Age
Pregnancy
Population
Obstetrics
Adrenal Cortex Hormones
Mothers
Lung
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Antenatal dexamethasone and decreased birth weight. / Bloom, Steven L.; Sheffield, Jeanne S.; Mcintire, Donald D.; Leveno, Kenneth J.

In: Obstetrics and Gynecology, Vol. 97, No. 4, 2001, p. 485-490.

Research output: Contribution to journalArticle

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AU - Leveno, Kenneth J.

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N2 - Objective: To test the hypothesis that antenatal dexamethasone treatment to promote fetal lung maturation results in decreased birth weight corrected for gestational age. Methods: The birth weights of all dexamethasone-treated, singleton, live-born infants delivered at our hospital were compared with our overall obstetric population; a group of untreated infants frequency matched approximately 3:1 according to maternal race, infant sex, and gestational age at delivery; and an historical cohort of infants with an indication for dexamethasone but delivered in the 12 months before the introduction of corticosteroid therapy at our hospital. Results: Dexamethasone-treated infants (n = 961), when compared with either the overall population (n = 122,629) or matched controls (n = 2808), had significantly lower birth weights after adjustment for week of gestation (P < .001). Compared with the historical cohort of infants, the average birth weight of dexamethasone-treated infants was smaller by 12 g at 24-26 weeks, 63 g at 27-29 weeks, 161 g at 30-32 weeks, and 80 g at 33-34 weeks' gestation. Conclusion: Antenatal dexamethasone administered to promote fetal maturation is associated with diminished birth weight.

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