Anti-CCP antibody and rheumatoid factor concentrations predict greater disease activity in men with rheumatoid arthritis

Benjamin J. Miriovsky, Kaleb Michaud, Geoffrey M. Thiele, James R. O'Dell, Grant W. Cannon, Gail Kerr, J. Steuart Richards, Dannette Johnson, Liron Caplan, Andreas Reimold, Roderick Hooker, Ted R. Mikuls

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Objective: To examine associations of anti-cyclic citrullinated peptide (aCCP) antibody and rheumatoid factor (RF) concentrations with future disease activity in men with rheumatoid arthritis (RA). Methods: Outcome measures were examined in male US veterans with RA and included (1) proportion of observations in remission (disease activity score (DAS28) ≤2.6); (2) remission for ≥3 consecutive months; and (3) area under the curve (AUC) for DAS28. The associations of autoantibody concentration (per 100 unit increments) with outcomes were examined using multivariate regression. Results: 826 men with RA were included in the analysis; the mean (SD) age was 65 (10.5) years and follow-up was for 2.6 (1.3) years. Most were aCCP (75%) and RF (80%) positive. After multivariate adjustment, aCCP (OR 0.93; 95% CI 0.89 to 0.96) and RF concentrations (OR 0.92; 95% CI 0.90 to 0.94) were associated with a lower odds of remission, a lower proportion of observation in remission (p=0.017 and p=0.002, respectively) and greater AUC DAS28 (p=0.092 and p=0.007, respectively). Among patients with discordant autoantibody status, higher concentrations of both aCCP and RF trended towards an inverse association with remission (OR 0.93; 95% CI 0.83 to 1.05 and OR 0.80; 95% CI 0.59 to 1.10, respectively). Conclusions: Higher aCCP concentrations (particularly in RF-positive patients) are associated with increased disease activity in US veterans with RA, indicating that aCCP concentration is predictive of future disease outcomes in men.

Original languageEnglish (US)
Pages (from-to)1292-1297
Number of pages6
JournalAnnals of the Rheumatic Diseases
Volume69
Issue number7
DOIs
StatePublished - Jul 2010

Fingerprint

Rheumatoid Factor
Anti-Idiotypic Antibodies
Rheumatoid Arthritis
Antibodies
Veterans
Autoantibodies
Area Under Curve
cyclic citrullinated peptide
Observation
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

Cite this

Miriovsky, B. J., Michaud, K., Thiele, G. M., O'Dell, J. R., Cannon, G. W., Kerr, G., ... Mikuls, T. R. (2010). Anti-CCP antibody and rheumatoid factor concentrations predict greater disease activity in men with rheumatoid arthritis. Annals of the Rheumatic Diseases, 69(7), 1292-1297. https://doi.org/10.1136/ard.2009.122739

Anti-CCP antibody and rheumatoid factor concentrations predict greater disease activity in men with rheumatoid arthritis. / Miriovsky, Benjamin J.; Michaud, Kaleb; Thiele, Geoffrey M.; O'Dell, James R.; Cannon, Grant W.; Kerr, Gail; Richards, J. Steuart; Johnson, Dannette; Caplan, Liron; Reimold, Andreas; Hooker, Roderick; Mikuls, Ted R.

In: Annals of the Rheumatic Diseases, Vol. 69, No. 7, 07.2010, p. 1292-1297.

Research output: Contribution to journalArticle

Miriovsky, BJ, Michaud, K, Thiele, GM, O'Dell, JR, Cannon, GW, Kerr, G, Richards, JS, Johnson, D, Caplan, L, Reimold, A, Hooker, R & Mikuls, TR 2010, 'Anti-CCP antibody and rheumatoid factor concentrations predict greater disease activity in men with rheumatoid arthritis', Annals of the Rheumatic Diseases, vol. 69, no. 7, pp. 1292-1297. https://doi.org/10.1136/ard.2009.122739
Miriovsky, Benjamin J. ; Michaud, Kaleb ; Thiele, Geoffrey M. ; O'Dell, James R. ; Cannon, Grant W. ; Kerr, Gail ; Richards, J. Steuart ; Johnson, Dannette ; Caplan, Liron ; Reimold, Andreas ; Hooker, Roderick ; Mikuls, Ted R. / Anti-CCP antibody and rheumatoid factor concentrations predict greater disease activity in men with rheumatoid arthritis. In: Annals of the Rheumatic Diseases. 2010 ; Vol. 69, No. 7. pp. 1292-1297.
@article{27b5f44a0f8c482ea682577783a33c99,
title = "Anti-CCP antibody and rheumatoid factor concentrations predict greater disease activity in men with rheumatoid arthritis",
abstract = "Objective: To examine associations of anti-cyclic citrullinated peptide (aCCP) antibody and rheumatoid factor (RF) concentrations with future disease activity in men with rheumatoid arthritis (RA). Methods: Outcome measures were examined in male US veterans with RA and included (1) proportion of observations in remission (disease activity score (DAS28) ≤2.6); (2) remission for ≥3 consecutive months; and (3) area under the curve (AUC) for DAS28. The associations of autoantibody concentration (per 100 unit increments) with outcomes were examined using multivariate regression. Results: 826 men with RA were included in the analysis; the mean (SD) age was 65 (10.5) years and follow-up was for 2.6 (1.3) years. Most were aCCP (75{\%}) and RF (80{\%}) positive. After multivariate adjustment, aCCP (OR 0.93; 95{\%} CI 0.89 to 0.96) and RF concentrations (OR 0.92; 95{\%} CI 0.90 to 0.94) were associated with a lower odds of remission, a lower proportion of observation in remission (p=0.017 and p=0.002, respectively) and greater AUC DAS28 (p=0.092 and p=0.007, respectively). Among patients with discordant autoantibody status, higher concentrations of both aCCP and RF trended towards an inverse association with remission (OR 0.93; 95{\%} CI 0.83 to 1.05 and OR 0.80; 95{\%} CI 0.59 to 1.10, respectively). Conclusions: Higher aCCP concentrations (particularly in RF-positive patients) are associated with increased disease activity in US veterans with RA, indicating that aCCP concentration is predictive of future disease outcomes in men.",
author = "Miriovsky, {Benjamin J.} and Kaleb Michaud and Thiele, {Geoffrey M.} and O'Dell, {James R.} and Cannon, {Grant W.} and Gail Kerr and Richards, {J. Steuart} and Dannette Johnson and Liron Caplan and Andreas Reimold and Roderick Hooker and Mikuls, {Ted R.}",
year = "2010",
month = "7",
doi = "10.1136/ard.2009.122739",
language = "English (US)",
volume = "69",
pages = "1292--1297",
journal = "Annals of the Rheumatic Diseases",
issn = "0003-4967",
publisher = "BMJ Publishing Group",
number = "7",

}

TY - JOUR

T1 - Anti-CCP antibody and rheumatoid factor concentrations predict greater disease activity in men with rheumatoid arthritis

AU - Miriovsky, Benjamin J.

AU - Michaud, Kaleb

AU - Thiele, Geoffrey M.

AU - O'Dell, James R.

AU - Cannon, Grant W.

AU - Kerr, Gail

AU - Richards, J. Steuart

AU - Johnson, Dannette

AU - Caplan, Liron

AU - Reimold, Andreas

AU - Hooker, Roderick

AU - Mikuls, Ted R.

PY - 2010/7

Y1 - 2010/7

N2 - Objective: To examine associations of anti-cyclic citrullinated peptide (aCCP) antibody and rheumatoid factor (RF) concentrations with future disease activity in men with rheumatoid arthritis (RA). Methods: Outcome measures were examined in male US veterans with RA and included (1) proportion of observations in remission (disease activity score (DAS28) ≤2.6); (2) remission for ≥3 consecutive months; and (3) area under the curve (AUC) for DAS28. The associations of autoantibody concentration (per 100 unit increments) with outcomes were examined using multivariate regression. Results: 826 men with RA were included in the analysis; the mean (SD) age was 65 (10.5) years and follow-up was for 2.6 (1.3) years. Most were aCCP (75%) and RF (80%) positive. After multivariate adjustment, aCCP (OR 0.93; 95% CI 0.89 to 0.96) and RF concentrations (OR 0.92; 95% CI 0.90 to 0.94) were associated with a lower odds of remission, a lower proportion of observation in remission (p=0.017 and p=0.002, respectively) and greater AUC DAS28 (p=0.092 and p=0.007, respectively). Among patients with discordant autoantibody status, higher concentrations of both aCCP and RF trended towards an inverse association with remission (OR 0.93; 95% CI 0.83 to 1.05 and OR 0.80; 95% CI 0.59 to 1.10, respectively). Conclusions: Higher aCCP concentrations (particularly in RF-positive patients) are associated with increased disease activity in US veterans with RA, indicating that aCCP concentration is predictive of future disease outcomes in men.

AB - Objective: To examine associations of anti-cyclic citrullinated peptide (aCCP) antibody and rheumatoid factor (RF) concentrations with future disease activity in men with rheumatoid arthritis (RA). Methods: Outcome measures were examined in male US veterans with RA and included (1) proportion of observations in remission (disease activity score (DAS28) ≤2.6); (2) remission for ≥3 consecutive months; and (3) area under the curve (AUC) for DAS28. The associations of autoantibody concentration (per 100 unit increments) with outcomes were examined using multivariate regression. Results: 826 men with RA were included in the analysis; the mean (SD) age was 65 (10.5) years and follow-up was for 2.6 (1.3) years. Most were aCCP (75%) and RF (80%) positive. After multivariate adjustment, aCCP (OR 0.93; 95% CI 0.89 to 0.96) and RF concentrations (OR 0.92; 95% CI 0.90 to 0.94) were associated with a lower odds of remission, a lower proportion of observation in remission (p=0.017 and p=0.002, respectively) and greater AUC DAS28 (p=0.092 and p=0.007, respectively). Among patients with discordant autoantibody status, higher concentrations of both aCCP and RF trended towards an inverse association with remission (OR 0.93; 95% CI 0.83 to 1.05 and OR 0.80; 95% CI 0.59 to 1.10, respectively). Conclusions: Higher aCCP concentrations (particularly in RF-positive patients) are associated with increased disease activity in US veterans with RA, indicating that aCCP concentration is predictive of future disease outcomes in men.

UR - http://www.scopus.com/inward/record.url?scp=77955000386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955000386&partnerID=8YFLogxK

U2 - 10.1136/ard.2009.122739

DO - 10.1136/ard.2009.122739

M3 - Article

C2 - 20439294

AN - SCOPUS:77955000386

VL - 69

SP - 1292

EP - 1297

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

IS - 7

ER -