A phosphorylcholine binding protein in lysates from radioiodinated splenocytes of immunized mice was demonstrated. Immunoprecipitation with antireceptor antibody of lysates from splenocytes obtained from animals undergoing a primary response or from mice immunized 4 to 6 mth earlier with antigen demonstrated that this protein contained H and L chains. Therefore, an antigen specific receptor was isolated from the surface of spleen cells from both immunized and 'memory' animals. This receptor Ig comprises approximately 10% of total cell surface Ig.
|Original language||English (US)|
|Journal||Journal of Immunology|
|State||Published - Dec 1 1975|
ASJC Scopus subject areas
- Immunology and Allergy