Anti receptor antibody. I. Isolation and characterization of the immunoglobulin receptor for phosphorylcholine

D. S. Strayer, E. S. Vitetta, H. Kohler

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Abstract

A phosphorylcholine binding protein in lysates from radioiodinated splenocytes of immunized mice was demonstrated. Immunoprecipitation with antireceptor antibody of lysates from splenocytes obtained from animals undergoing a primary response or from mice immunized 4 to 6 mth earlier with antigen demonstrated that this protein contained H and L chains. Therefore, an antigen specific receptor was isolated from the surface of spleen cells from both immunized and 'memory' animals. This receptor Ig comprises approximately 10% of total cell surface Ig.

Original languageEnglish (US)
Pages (from-to)II
JournalJournal of Immunology
Volume114
Issue number2
StatePublished - Dec 1 1975

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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