Anticoagulation and continuous renal replacement therapy

Jamshid Amanzadeh, Robert F. Reilly

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

More than half of patients with acute renal failure in the intensive care unit require dialysis, and the majority of them have significant hemodynamic instability. Continuous renal replacement therapy (CRRT) is often the preferred dialysis modality in these patients. One requirement for CRRT is anticoagulation, which can expose patients to the risk of bleeding. However, absence of effective anticoagulation may result in clotting of the CRRT circuit and subsequently less effective treatment. While heparins are widely used for anticoagulation, because of potential side effects such as bleeding and heparin-induced thrombocytopenia, alternative anticoagulation protocols should be considered. Citrate anticoagulation, regional heparin/protamine, predilution, r-hirudin, prostacyclin, and nafamostat are among these methods.

Original languageEnglish (US)
Pages (from-to)311-316
Number of pages6
JournalSeminars in Dialysis
Volume19
Issue number4
DOIs
StatePublished - Jul 2006

Fingerprint

Renal Replacement Therapy
Heparin
Dialysis
Hemorrhage
Hirudins
Protamines
Epoprostenol
Acute Kidney Injury
Citric Acid
Thrombocytopenia
Intensive Care Units
Hemodynamics
Therapeutics

ASJC Scopus subject areas

  • Nephrology

Cite this

Anticoagulation and continuous renal replacement therapy. / Amanzadeh, Jamshid; Reilly, Robert F.

In: Seminars in Dialysis, Vol. 19, No. 4, 07.2006, p. 311-316.

Research output: Contribution to journalArticle

Amanzadeh, Jamshid ; Reilly, Robert F. / Anticoagulation and continuous renal replacement therapy. In: Seminars in Dialysis. 2006 ; Vol. 19, No. 4. pp. 311-316.
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