Antidepressant drugs: Additional clinical uses

P. J. Orsulak, D. Waller

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Three decades of psychiatric practice with tricyclic, tetracyclic, and heterocyclic antidepressants have shown that these drugs are effective not only for major depression, endogenous depression in particular, but also for a range of others disorders. Tricyclic and other antidepressants are now used to treat enuresis and attention-deficit disorders in children, bulimia and anorexia nervosa, panic disorder, posttrraumatic stress disorder, obsessive-compulsive disorder, chronic pain, migraine, and peptic ulcer disease. As with some of the antidepressants, the body of literature on the relationship between clinical response in these diseases and plasma or serum levels of the drugs is not complete or well understood, but for some of these disorders, sufficient preliminary serum level data are available to take advantage of therapeutic drug monitoring as an adjunct to treatment. Therapeutic monitoring can be particularly important where studies indicate that successful therapy occurs at blood levels substantially different from those used to treat depression. This paper presents a brief overview of antidepressant treatment of these disorders, focusing on the available pharmacologic data related to serum level measurements and their relation to clinical response.

Original languageEnglish (US)
Pages (from-to)209-216
Number of pages8
JournalJournal of Family Practice
Volume28
Issue number2
StatePublished - 1989

Fingerprint

Antidepressive Agents
Serum
Depression
Enuresis
Bulimia Nervosa
Drug Monitoring
Tricyclic Antidepressive Agents
Panic Disorder
Obsessive-Compulsive Disorder
Anorexia Nervosa
Therapeutics
Attention Deficit Disorder with Hyperactivity
Depressive Disorder
Peptic Ulcer
Migraine Disorders
Chronic Pain
Pharmaceutical Preparations
Psychiatry

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Antidepressant drugs : Additional clinical uses. / Orsulak, P. J.; Waller, D.

In: Journal of Family Practice, Vol. 28, No. 2, 1989, p. 209-216.

Research output: Contribution to journalArticle

Orsulak, P. J. ; Waller, D. / Antidepressant drugs : Additional clinical uses. In: Journal of Family Practice. 1989 ; Vol. 28, No. 2. pp. 209-216.
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