Antidepressant medication treatment failure does not predict lower remission with ECT for major depressive disorder: A report from the consortium for research in electroconvulsive therapy

Keith G. Rasmussen, Martina Mueller, Rebecca G. Knapp, Mustafa M. Husain, Teresa A. Rummans, Shirlene M. Sampson, M. Kevin O'Connor, Georgios Petrides, Max Fink, Charles H. Kellner

Research output: Contribution to journalArticle

32 Scopus citations


Objective: To test whether antidepressant medication treatment failure predicts differential remission with electroconvulsive therapy (ECT) in nonpsychotic unipolar depression. Method: Depressed patients diagnosed with the Structured Clinical Interview for DSM-IV receiving ECT were assessed for medication use with the Antidepressant Treatment History Form (ATHF) (N = 345). Response to ECT was assessed with the 24-item Hamilton Rating Scale for Depression. Baseline medication treatment failure was analyzed as a possible predictor of remission status. Dates of study enrollment were from May 1997 to July 2004. Results: Resistance to antidepressant medication as assessed by the ATHF, either taken as a whole or for any individual class of medication, was not predictive of acute remission status with ECT. Conclusion: Treatment failure with antidepressant medication does not predict acute remission status with ECT for nonpsychotically depressed patients.

Original languageEnglish (US)
Pages (from-to)1701-1706
Number of pages6
JournalJournal of Clinical Psychiatry
Issue number11
StatePublished - Nov 2007


ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this