Antihypertensive Drugs in Combination: Effects of Methyldopa on Thiazide-Induced Changes in Renal Hemodynamics and Plasma Renin Activity

Norman M Kaplan

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3 Scopus citations


The rise in plasma renin activity (PRA) that accompanies thiazide diuretic therapy of hypertension may interfere with therapeutic effectiveness and contribute to hypokalemia. In an attempt to provide a basis for the previously empiric use of antihypertensive drugs, 20 hypertensive subjects were given a diuretic alone for three weeks and a diuretic plus methyldopa, which lowers PRA, for three weeks. The thiazide-induced rise in PRA was blunted by the methyldopa, while blood pressure fell even more and renal function was well maintained. The combination of a renin-lowering drug and a diuretic is rational and effective therapy for hypertension.

Original languageEnglish (US)
Pages (from-to)660-663
Number of pages4
JournalArchives of Internal Medicine
Issue number5
StatePublished - May 1975


ASJC Scopus subject areas

  • Internal Medicine

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