Antileukotriene therapy for the relief of sinus symptoms in aspirin triad disease

Seckin O. Ulualp, Bruce M. Sterman, Robert J. Toohill Md

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

We studied the effect of antileukotriene therapy for the relief of sinus symptoms in patients with aspirin triad disease (ATD). We reviewed the charts of 18 ATD patients who had received antileukotriene therapy. All patients had undergone previous sinus surgery. We then designed a questionnaire to determine the level of each patient's symptoms of chronic rhinosinusitis before and after antileukotriene therapy. Responses were converted to symptom scores. For each patient, the role of therapy in the relief of sinus symptoms was evaluated in three ways: by total symptom scores, by self-reports of overall benefit, and by findings on endoscopic nasal examination. Fifteen of the 18 patients completed the questionnaire. Symptom scores for both major and minor symptoms indicated that nine patients had improved following antileukotriene therapy; three other patients reported some overall benefit from therapy, despite no improvement in their symptom scores. Endoscopic nasal examination findings were consistent with the reports of overall benefit. We conclude that antileukotriene therapy is an effective treatment for most patients whose symptoms of chronic rhinosinusitis persist following sinus surgery.

Original languageEnglish (US)
Pages (from-to)604-616
Number of pages13
JournalEar, Nose and Throat Journal
Volume78
Issue number8
StatePublished - 1999

Fingerprint

Aspirin
Therapeutics
Nose
Self Report

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Antileukotriene therapy for the relief of sinus symptoms in aspirin triad disease. / Ulualp, Seckin O.; Sterman, Bruce M.; Toohill Md, Robert J.

In: Ear, Nose and Throat Journal, Vol. 78, No. 8, 1999, p. 604-616.

Research output: Contribution to journalArticle

Ulualp, Seckin O. ; Sterman, Bruce M. ; Toohill Md, Robert J. / Antileukotriene therapy for the relief of sinus symptoms in aspirin triad disease. In: Ear, Nose and Throat Journal. 1999 ; Vol. 78, No. 8. pp. 604-616.
@article{f885e1dcc5fa4ed6b88f26d7a75ba43b,
title = "Antileukotriene therapy for the relief of sinus symptoms in aspirin triad disease",
abstract = "We studied the effect of antileukotriene therapy for the relief of sinus symptoms in patients with aspirin triad disease (ATD). We reviewed the charts of 18 ATD patients who had received antileukotriene therapy. All patients had undergone previous sinus surgery. We then designed a questionnaire to determine the level of each patient's symptoms of chronic rhinosinusitis before and after antileukotriene therapy. Responses were converted to symptom scores. For each patient, the role of therapy in the relief of sinus symptoms was evaluated in three ways: by total symptom scores, by self-reports of overall benefit, and by findings on endoscopic nasal examination. Fifteen of the 18 patients completed the questionnaire. Symptom scores for both major and minor symptoms indicated that nine patients had improved following antileukotriene therapy; three other patients reported some overall benefit from therapy, despite no improvement in their symptom scores. Endoscopic nasal examination findings were consistent with the reports of overall benefit. We conclude that antileukotriene therapy is an effective treatment for most patients whose symptoms of chronic rhinosinusitis persist following sinus surgery.",
author = "Ulualp, {Seckin O.} and Sterman, {Bruce M.} and {Toohill Md}, {Robert J.}",
year = "1999",
language = "English (US)",
volume = "78",
pages = "604--616",
journal = "Ear, Nose and Throat Journal",
issn = "0145-5613",
publisher = "Medquest Communications LLC",
number = "8",

}

TY - JOUR

T1 - Antileukotriene therapy for the relief of sinus symptoms in aspirin triad disease

AU - Ulualp, Seckin O.

AU - Sterman, Bruce M.

AU - Toohill Md, Robert J.

PY - 1999

Y1 - 1999

N2 - We studied the effect of antileukotriene therapy for the relief of sinus symptoms in patients with aspirin triad disease (ATD). We reviewed the charts of 18 ATD patients who had received antileukotriene therapy. All patients had undergone previous sinus surgery. We then designed a questionnaire to determine the level of each patient's symptoms of chronic rhinosinusitis before and after antileukotriene therapy. Responses were converted to symptom scores. For each patient, the role of therapy in the relief of sinus symptoms was evaluated in three ways: by total symptom scores, by self-reports of overall benefit, and by findings on endoscopic nasal examination. Fifteen of the 18 patients completed the questionnaire. Symptom scores for both major and minor symptoms indicated that nine patients had improved following antileukotriene therapy; three other patients reported some overall benefit from therapy, despite no improvement in their symptom scores. Endoscopic nasal examination findings were consistent with the reports of overall benefit. We conclude that antileukotriene therapy is an effective treatment for most patients whose symptoms of chronic rhinosinusitis persist following sinus surgery.

AB - We studied the effect of antileukotriene therapy for the relief of sinus symptoms in patients with aspirin triad disease (ATD). We reviewed the charts of 18 ATD patients who had received antileukotriene therapy. All patients had undergone previous sinus surgery. We then designed a questionnaire to determine the level of each patient's symptoms of chronic rhinosinusitis before and after antileukotriene therapy. Responses were converted to symptom scores. For each patient, the role of therapy in the relief of sinus symptoms was evaluated in three ways: by total symptom scores, by self-reports of overall benefit, and by findings on endoscopic nasal examination. Fifteen of the 18 patients completed the questionnaire. Symptom scores for both major and minor symptoms indicated that nine patients had improved following antileukotriene therapy; three other patients reported some overall benefit from therapy, despite no improvement in their symptom scores. Endoscopic nasal examination findings were consistent with the reports of overall benefit. We conclude that antileukotriene therapy is an effective treatment for most patients whose symptoms of chronic rhinosinusitis persist following sinus surgery.

UR - http://www.scopus.com/inward/record.url?scp=0032782372&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032782372&partnerID=8YFLogxK

M3 - Article

C2 - 10485156

AN - SCOPUS:0032782372

VL - 78

SP - 604

EP - 616

JO - Ear, Nose and Throat Journal

JF - Ear, Nose and Throat Journal

SN - 0145-5613

IS - 8

ER -