Antinuclear antibodies (ANA) and complement fixing ANA in systemic connective tissue diseases

Ernst H. Beutner, Walter L. Binder, Yisheng V. Fang, Richard W. Plunkett, Robert L. Rubin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Screening for antinuclear antibodies (ANA) with parallel tests for complement fixing ANA (C-ANA) reveal that C-ANA react either as strongly as or more strongly than ANA in most cases of systemic lupus erythematosus (SLE) and related disorders including CREST syndrome. But sera of drug induced LE and other ANA positive subjects have weak or no C-ANA. (P < 0.0005). Titrations with parallel C-ANA/ANA tests of two cases reveal primarily ANA and less C-ANA reactions in a case of drug induced LE but in CREST syndrome both ANA and C-ANA tests yield elevated titers with stronger C-ANA reactions. These findings point to distinct immunochemical mechanisms in C-ANA and ANA reactions.

Original languageEnglish (US)
Pages (from-to)97-104
Number of pages8
JournalImmunological Investigations
Volume27
Issue number1-2
StatePublished - 1998

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Connective Tissue Diseases
Antinuclear Antibodies
CREST Syndrome
Pharmaceutical Preparations
Systemic Lupus Erythematosus
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Beutner, E. H., Binder, W. L., Fang, Y. V., Plunkett, R. W., & Rubin, R. L. (1998). Antinuclear antibodies (ANA) and complement fixing ANA in systemic connective tissue diseases. Immunological Investigations, 27(1-2), 97-104.

Antinuclear antibodies (ANA) and complement fixing ANA in systemic connective tissue diseases. / Beutner, Ernst H.; Binder, Walter L.; Fang, Yisheng V.; Plunkett, Richard W.; Rubin, Robert L.

In: Immunological Investigations, Vol. 27, No. 1-2, 1998, p. 97-104.

Research output: Contribution to journalArticle

Beutner, EH, Binder, WL, Fang, YV, Plunkett, RW & Rubin, RL 1998, 'Antinuclear antibodies (ANA) and complement fixing ANA in systemic connective tissue diseases', Immunological Investigations, vol. 27, no. 1-2, pp. 97-104.
Beutner, Ernst H. ; Binder, Walter L. ; Fang, Yisheng V. ; Plunkett, Richard W. ; Rubin, Robert L. / Antinuclear antibodies (ANA) and complement fixing ANA in systemic connective tissue diseases. In: Immunological Investigations. 1998 ; Vol. 27, No. 1-2. pp. 97-104.
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