Antithyroid antibodies and parity: Further evidence for microchimerism in autoimmune thyroid disease

Laura G. Greer, Brian M. Casey, Lisa M. Halvorson, Catherine Y. Spong, Donald D. McIntire, F. Gary Cunningham

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Objective: Fetal microchimerism may have a role in development of autoimmune thyroid disorders. Using parity as a surrogate for increasing fetal cell exposure, we analyzed its association with thyroid peroxidase antibody levels. Study Design: Secondary analysis of serum thyroid analytes determined in 17,298 women from a population-based prospective study between 2001 and 2003. Sera were assayed for thyrotropin, free thyroxine, and antithyroid peroxidase antibodies. We analyzed the relationship between thyroid peroxidase antibodies and increasing parity. Results: The incidence of abnormally elevated thyroid peroxidase antibody levels (>50 IU/mL) increased with advancing parity, but was not significant after adjustment for maternal characteristics. However, at higher thyroid peroxidase antibody levels (>500 IU/mL), a significant relationship with advancing parity persisted after adjustments (P =.002). Conclusion: Advancing parity is associated with an increased risk for high serum concentrations of antithyroid peroxidase antibodies. This suggests fetal microchimerism may play a role in development of autoimmune thyroid disorders.

Original languageEnglish (US)
Pages (from-to)471.e1-471.e4
JournalAmerican journal of obstetrics and gynecology
Volume205
Issue number5
DOIs
StatePublished - Nov 2011

Keywords

  • autoimmune thyroid disease
  • microchimerism
  • thyroid peroxidase antibody

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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