Antitumour immune responses.

Roshni Mitra, Sarvjeet Singh, Ashok Khar

Research output: Contribution to journalReview article

Abstract

The role of the immune system in combating tumour progression has been studied extensively. The two branches of the immune response - humoral and cell-mediated - act both independently and in concert to combat tumour progression, the success of which depends on the immunogenicity of the tumour cells. The immune system discriminates between transformed cells and normal cells by virtue of the presence of unique antigens on tumour cells.Despite this, the immune system is not always able to detect and kill cancerous cells because neoplasms have also evolved various strategies to escape immune surveillance. Attempts are being made to trigger the immune system into an early and efficient response against malignant cells, and various therapeutic modalities are being developed to enhance the strength of the immune response against tumours. This review aims to elucidate the tumoricidal role of various components of the immune system, including macrophages, lymphocytes, dendritic cells and complement.

Original languageEnglish (US)
Pages (from-to)1-19
Number of pages19
JournalExpert Reviews in Molecular Medicine
Volume5
Issue number3
Publication statusPublished - Jan 1 2003

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Molecular Medicine

Cite this

Mitra, R., Singh, S., & Khar, A. (2003). Antitumour immune responses. Expert Reviews in Molecular Medicine, 5(3), 1-19.