Apical-basal polarity, Wnt signaling and vertebrate organogenesis

Courtney Karner, Keith A. Wharton, Thomas J. Carroll

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Wnt proteins elicit several distinct signal transduction cascades and regulate multiple cellular processes that have proven essential for embryonic development in all metazoans investigated. During embryonic development, epithelial cells become polarized along two axes: apical/basal and within the plane of the tissue. Growing evidence suggests that polarization along each axis is essential for normal embryonic development and that this polarization is regulated in part by the different branches of the Wnt pathway. Here, we review the role of A/B cell polarity in vertebrate organogenesis with a focus on the involvement of canonical Wnt signaling in this process.

Original languageEnglish (US)
Pages (from-to)214-222
Number of pages9
JournalSeminars in Cell and Developmental Biology
Volume17
Issue number2
DOIs
StatePublished - Apr 2006

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Organogenesis
Embryonic Development
Vertebrates
Wnt Proteins
Cell Polarity
Wnt Signaling Pathway
Signal Transduction
B-Lymphocytes
Epithelial Cells

Keywords

  • Non-canonical
  • Organogenesis
  • Planar cell polarity, Tissue polarity
  • Wnt

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Apical-basal polarity, Wnt signaling and vertebrate organogenesis. / Karner, Courtney; Wharton, Keith A.; Carroll, Thomas J.

In: Seminars in Cell and Developmental Biology, Vol. 17, No. 2, 04.2006, p. 214-222.

Research output: Contribution to journalArticle

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