Apolipoprotein E receptors in the nervous system

Research output: Contribution to journalReview article

53 Scopus citations

Abstract

ApoE, a common ligand for all members of the evolutionary ancient LDL receptor gene family, is the major genetic modifier of the age of onset of Alzheimer's disease. The underlying molecular mechanisms remain shrouded in mystery, but the numerous critical functions of ApoE receptors within and outside the nervous system that have recently emerged make it likely that these multifunctional signal modulators participate in Alzheimer's disease pathogenesis. This review attempts to summarize the most recent and relevant findings in this area.

Original languageEnglish (US)
Pages (from-to)190-196
Number of pages7
JournalCurrent opinion in lipidology
Volume20
Issue number3
DOIs
StatePublished - Jun 2009

Keywords

  • Dementia
  • LDL receptor family
  • Neuronal survival
  • Synaptic plasticity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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