Apoptotic cell death in Drosophila

Kathleen Galindo, John M. Abrams

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In animals, programmed cell death (PCD) is a universal feature of development and is critical for adaptive responses during cellular injury. In both vertebrates and invertebrates, dying cells often progress through a series of ultrastructural changes referred to as apoptosis. This form of PCD involves condensation of nuclear material and fragmentation into “ apoptotic bodies” that are eventually engulfed by phagocytes. It is well established that apoptosis requires genetic functions within the dying cell and that the underlying molecular machinery is evolutionarily conserved. Studies in model systems have elaborated common control points in pathways that regulate cell death. However, when considered within larger networks of interactions, the importance of these regulatory “ linchpins” can vary across different cell types and across different species. Here, we consider these similarities and differences and discuss how the Drosophila model organism may shed light on evolutionary pressures that fundamentally shaped this biological process.

Original languageEnglish (US)
Title of host publicationApoptosis: Physiology and Pathology
PublisherCambridge University Press
Pages407-411
Number of pages5
ISBN (Print)9780511976094, 9780521886567
DOIs
StatePublished - Jan 1 2011

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Galindo, K., & Abrams, J. M. (2011). Apoptotic cell death in Drosophila. In Apoptosis: Physiology and Pathology (pp. 407-411). Cambridge University Press. https://doi.org/10.1017/CBO9780511976094.035