Aquaporin-4 neuromyelitis optica spectrum disorder in a 2-year-old girl: Diagnostic and treatment considerations

Tuba Rashid Khan; Cynthia Wang

doi:10.1016/j.msard.2020.102030

Aquaporin-4 neuromyelitis optica spectrum disorder in a 2-year-old girl: Diagnostic and treatment considerations

Tuba Rashid Khan, Cynthia Wang

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We describe a case of an unusually early and severe manifestation of Aquaporin-4 (AQP-4) positive Neuromyelitis Optica Spectrum Disorder (NMOSD) in a two-year-old girl. We discuss learning points from her clinical presentation and highlight differences between pediatric and adult presentations of the disease. We argue that AQP-4 NMOSD should always be considered in the differential diagnosis for any child presenting with an acute neuroimmunological process given the morbidity associated with the condition and the importance of early diagnosis and treatment.

Original language	English (US)
Article number	102030
Journal	Multiple Sclerosis and Related Disorders
Volume	41
DOIs	https://doi.org/10.1016/j.msard.2020.102030
State	Published - Jun 2020

Keywords

Aquaporin-4
Autoimmune neurology
Neuroimmunology
Neuromyelitis optica

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/j.msard.2020.102030

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title = "Aquaporin-4 neuromyelitis optica spectrum disorder in a 2-year-old girl: Diagnostic and treatment considerations",

abstract = "We describe a case of an unusually early and severe manifestation of Aquaporin-4 (AQP-4) positive Neuromyelitis Optica Spectrum Disorder (NMOSD) in a two-year-old girl. We discuss learning points from her clinical presentation and highlight differences between pediatric and adult presentations of the disease. We argue that AQP-4 NMOSD should always be considered in the differential diagnosis for any child presenting with an acute neuroimmunological process given the morbidity associated with the condition and the importance of early diagnosis and treatment.",

keywords = "Aquaporin-4, Autoimmune neurology, Neuroimmunology, Neuromyelitis optica",

author = "Khan, {Tuba Rashid} and Cynthia Wang",

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year = "2020",

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doi = "10.1016/j.msard.2020.102030",

language = "English (US)",

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T2 - Diagnostic and treatment considerations

AU - Khan, Tuba Rashid

AU - Wang, Cynthia

PY - 2020/6

Y1 - 2020/6

N2 - We describe a case of an unusually early and severe manifestation of Aquaporin-4 (AQP-4) positive Neuromyelitis Optica Spectrum Disorder (NMOSD) in a two-year-old girl. We discuss learning points from her clinical presentation and highlight differences between pediatric and adult presentations of the disease. We argue that AQP-4 NMOSD should always be considered in the differential diagnosis for any child presenting with an acute neuroimmunological process given the morbidity associated with the condition and the importance of early diagnosis and treatment.

AB - We describe a case of an unusually early and severe manifestation of Aquaporin-4 (AQP-4) positive Neuromyelitis Optica Spectrum Disorder (NMOSD) in a two-year-old girl. We discuss learning points from her clinical presentation and highlight differences between pediatric and adult presentations of the disease. We argue that AQP-4 NMOSD should always be considered in the differential diagnosis for any child presenting with an acute neuroimmunological process given the morbidity associated with the condition and the importance of early diagnosis and treatment.

KW - Aquaporin-4

KW - Autoimmune neurology

KW - Neuroimmunology

KW - Neuromyelitis optica

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JO - Multiple Sclerosis and Related Disorders

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ER -

Aquaporin-4 neuromyelitis optica spectrum disorder in a 2-year-old girl: Diagnostic and treatment considerations

Abstract

Keywords

ASJC Scopus subject areas

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