Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer

Xuxu Sun, Sam C. Wang, Yonglong Wei, Xin Luo, Yuemeng Jia, Lin Li, Purva Gopal, Min Zhu, Ibrahim Nassour, Jen Chieh Chuang, Thomas Maples, Cemre Celen, Liem H. Nguyen, Linwei Wu, Shunjun Fu, Weiping Li, Lijian Hui, Feng Tian, Yuan Ji, Shuyuan ZhangMahsa Sorouri, Tae Hyun Hwang, Lynda Letzig, Laura James, Zixi Wang, Adam C. Yopp, Amit G. Singal, Hao Zhu

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

ARID1A, an SWI/SNF chromatin-remodeling gene, is commonly mutated in cancer and hypothesized to be tumor suppressive. In some hepatocellular carcinoma patients, ARID1A was highly expressed in primary tumors but not in metastatic lesions, suggesting that ARID1A can be lost after initiation. Mice with liver-specific homozygous or heterozygous Arid1a loss were resistant to tumor initiation while ARID1A overexpression accelerated initiation. In contrast, homozygous or heterozygous Arid1a loss in established tumors accelerated progression and metastasis. Mechanistically, gain of Arid1a function promoted initiation by increasing CYP450-mediated oxidative stress, while loss of Arid1a within tumors decreased chromatin accessibility and reduced transcription of genes associated with migration, invasion, and metastasis. In summary, ARID1A has context-dependent tumor-suppressive and oncogenic roles in cancer. Sun el al. uncover context-specific roles for the SWI/SNF component Arid1a in liver cancer, where elevated Arid1a promotes tumor initiation through CYP450-mediated oxidative stress, whereas reduced Arid1a in established tumors increases metastasis due to reduced expression of inhibitory factors.

Original languageEnglish (US)
Pages (from-to)574-589.e6
JournalCancer Cell
Volume32
Issue number5
DOIs
StatePublished - Nov 13 2017

Fingerprint

Liver Neoplasms
Neoplasms
Neoplasm Metastasis
Oxidative Stress
Chromatin Assembly and Disassembly
Solar System
Genes
Chromatin
Hepatocellular Carcinoma
Liver

Keywords

  • ARID1A
  • epigenetics
  • hepatocellular carcinoma
  • metastasis
  • mouse models
  • SWI/SNF chromatin-remodeling complex

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer. / Sun, Xuxu; Wang, Sam C.; Wei, Yonglong; Luo, Xin; Jia, Yuemeng; Li, Lin; Gopal, Purva; Zhu, Min; Nassour, Ibrahim; Chuang, Jen Chieh; Maples, Thomas; Celen, Cemre; Nguyen, Liem H.; Wu, Linwei; Fu, Shunjun; Li, Weiping; Hui, Lijian; Tian, Feng; Ji, Yuan; Zhang, Shuyuan; Sorouri, Mahsa; Hwang, Tae Hyun; Letzig, Lynda; James, Laura; Wang, Zixi; Yopp, Adam C.; Singal, Amit G.; Zhu, Hao.

In: Cancer Cell, Vol. 32, No. 5, 13.11.2017, p. 574-589.e6.

Research output: Contribution to journalArticle

Sun, X, Wang, SC, Wei, Y, Luo, X, Jia, Y, Li, L, Gopal, P, Zhu, M, Nassour, I, Chuang, JC, Maples, T, Celen, C, Nguyen, LH, Wu, L, Fu, S, Li, W, Hui, L, Tian, F, Ji, Y, Zhang, S, Sorouri, M, Hwang, TH, Letzig, L, James, L, Wang, Z, Yopp, AC, Singal, AG & Zhu, H 2017, 'Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer', Cancer Cell, vol. 32, no. 5, pp. 574-589.e6. https://doi.org/10.1016/j.ccell.2017.10.007
Sun, Xuxu ; Wang, Sam C. ; Wei, Yonglong ; Luo, Xin ; Jia, Yuemeng ; Li, Lin ; Gopal, Purva ; Zhu, Min ; Nassour, Ibrahim ; Chuang, Jen Chieh ; Maples, Thomas ; Celen, Cemre ; Nguyen, Liem H. ; Wu, Linwei ; Fu, Shunjun ; Li, Weiping ; Hui, Lijian ; Tian, Feng ; Ji, Yuan ; Zhang, Shuyuan ; Sorouri, Mahsa ; Hwang, Tae Hyun ; Letzig, Lynda ; James, Laura ; Wang, Zixi ; Yopp, Adam C. ; Singal, Amit G. ; Zhu, Hao. / Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer. In: Cancer Cell. 2017 ; Vol. 32, No. 5. pp. 574-589.e6.
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abstract = "ARID1A, an SWI/SNF chromatin-remodeling gene, is commonly mutated in cancer and hypothesized to be tumor suppressive. In some hepatocellular carcinoma patients, ARID1A was highly expressed in primary tumors but not in metastatic lesions, suggesting that ARID1A can be lost after initiation. Mice with liver-specific homozygous or heterozygous Arid1a loss were resistant to tumor initiation while ARID1A overexpression accelerated initiation. In contrast, homozygous or heterozygous Arid1a loss in established tumors accelerated progression and metastasis. Mechanistically, gain of Arid1a function promoted initiation by increasing CYP450-mediated oxidative stress, while loss of Arid1a within tumors decreased chromatin accessibility and reduced transcription of genes associated with migration, invasion, and metastasis. In summary, ARID1A has context-dependent tumor-suppressive and oncogenic roles in cancer. Sun el al. uncover context-specific roles for the SWI/SNF component Arid1a in liver cancer, where elevated Arid1a promotes tumor initiation through CYP450-mediated oxidative stress, whereas reduced Arid1a in established tumors increases metastasis due to reduced expression of inhibitory factors.",
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AU - Sun, Xuxu

AU - Wang, Sam C.

AU - Wei, Yonglong

AU - Luo, Xin

AU - Jia, Yuemeng

AU - Li, Lin

AU - Gopal, Purva

AU - Zhu, Min

AU - Nassour, Ibrahim

AU - Chuang, Jen Chieh

AU - Maples, Thomas

AU - Celen, Cemre

AU - Nguyen, Liem H.

AU - Wu, Linwei

AU - Fu, Shunjun

AU - Li, Weiping

AU - Hui, Lijian

AU - Tian, Feng

AU - Ji, Yuan

AU - Zhang, Shuyuan

AU - Sorouri, Mahsa

AU - Hwang, Tae Hyun

AU - Letzig, Lynda

AU - James, Laura

AU - Wang, Zixi

AU - Yopp, Adam C.

AU - Singal, Amit G.

AU - Zhu, Hao

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AB - ARID1A, an SWI/SNF chromatin-remodeling gene, is commonly mutated in cancer and hypothesized to be tumor suppressive. In some hepatocellular carcinoma patients, ARID1A was highly expressed in primary tumors but not in metastatic lesions, suggesting that ARID1A can be lost after initiation. Mice with liver-specific homozygous or heterozygous Arid1a loss were resistant to tumor initiation while ARID1A overexpression accelerated initiation. In contrast, homozygous or heterozygous Arid1a loss in established tumors accelerated progression and metastasis. Mechanistically, gain of Arid1a function promoted initiation by increasing CYP450-mediated oxidative stress, while loss of Arid1a within tumors decreased chromatin accessibility and reduced transcription of genes associated with migration, invasion, and metastasis. In summary, ARID1A has context-dependent tumor-suppressive and oncogenic roles in cancer. Sun el al. uncover context-specific roles for the SWI/SNF component Arid1a in liver cancer, where elevated Arid1a promotes tumor initiation through CYP450-mediated oxidative stress, whereas reduced Arid1a in established tumors increases metastasis due to reduced expression of inhibitory factors.

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