Arterial transit time imaging with flow encoding arterial spin tagging (FEAST)

Jiongjiong Wang, David C. Alsop, Hee Kwon Song, Joseph A Maldjian, Kathy Tang, Alana E. Salvucci, John A. Detre

Research output: Contribution to journalArticle

178 Citations (Scopus)

Abstract

Arterial spin labeling (ASL) perfusion imaging provides direct and absolute measurement of cerebral blood flow (CBF). Arterial transit time is a related physiological parameter reflecting the duration for the labeled spins to reach the brain region of interest. Most of the existing ASL approaches to assess arterial transit time rely on multiple measurements at various postlabeling delay times, and thus are vulnerable to motion artifact as well as computational error. We describe the use of flow encoding arterial spin tagging (FEAST) technique to measure tissue transit time, which can be derived from the ratio between the ASL signals measured with and without appropriate bipolar gradients. In the present study, we provided a theoretical framework and carried out an experimental validation during steady-state imaging. The global mean tissue transit time was ∼1100 and 1400 ms for two conditions of bipolar gradients with specific encoding velocity (Venc) of 29 and 8 mm/sec, respectively. The mean tissue transit time measured within cerebral vascular territories was shortest in the deep middle cerebral artery (MCA) territory. Application of the FEAST technique in two patients with cerebrovascular disease demonstrated prolonged tissue transit times in the affected vascular territories which were consistent with results from other MR imaging modalities.

Original languageEnglish (US)
Pages (from-to)599-607
Number of pages9
JournalMagnetic Resonance in Medicine
Volume50
Issue number3
DOIs
StatePublished - Sep 1 2003

Fingerprint

Blood Vessels
Cerebrovascular Circulation
Cerebrovascular Disorders
Perfusion Imaging
Middle Cerebral Artery
Artifacts
Brain

Keywords

  • Arterial spin labeling (ASL)
  • Cerebral blood flow (CBF)
  • Flow encoding arterial spin tagging (FEAST)
  • Functional brain imaging
  • Tissue transit time

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Wang, J., Alsop, D. C., Song, H. K., Maldjian, J. A., Tang, K., Salvucci, A. E., & Detre, J. A. (2003). Arterial transit time imaging with flow encoding arterial spin tagging (FEAST). Magnetic Resonance in Medicine, 50(3), 599-607. https://doi.org/10.1002/mrm.10559

Arterial transit time imaging with flow encoding arterial spin tagging (FEAST). / Wang, Jiongjiong; Alsop, David C.; Song, Hee Kwon; Maldjian, Joseph A; Tang, Kathy; Salvucci, Alana E.; Detre, John A.

In: Magnetic Resonance in Medicine, Vol. 50, No. 3, 01.09.2003, p. 599-607.

Research output: Contribution to journalArticle

Wang, J, Alsop, DC, Song, HK, Maldjian, JA, Tang, K, Salvucci, AE & Detre, JA 2003, 'Arterial transit time imaging with flow encoding arterial spin tagging (FEAST)', Magnetic Resonance in Medicine, vol. 50, no. 3, pp. 599-607. https://doi.org/10.1002/mrm.10559
Wang, Jiongjiong ; Alsop, David C. ; Song, Hee Kwon ; Maldjian, Joseph A ; Tang, Kathy ; Salvucci, Alana E. ; Detre, John A. / Arterial transit time imaging with flow encoding arterial spin tagging (FEAST). In: Magnetic Resonance in Medicine. 2003 ; Vol. 50, No. 3. pp. 599-607.
@article{bd72623c4b4144a6bb3d5076a6601bc7,
title = "Arterial transit time imaging with flow encoding arterial spin tagging (FEAST)",
abstract = "Arterial spin labeling (ASL) perfusion imaging provides direct and absolute measurement of cerebral blood flow (CBF). Arterial transit time is a related physiological parameter reflecting the duration for the labeled spins to reach the brain region of interest. Most of the existing ASL approaches to assess arterial transit time rely on multiple measurements at various postlabeling delay times, and thus are vulnerable to motion artifact as well as computational error. We describe the use of flow encoding arterial spin tagging (FEAST) technique to measure tissue transit time, which can be derived from the ratio between the ASL signals measured with and without appropriate bipolar gradients. In the present study, we provided a theoretical framework and carried out an experimental validation during steady-state imaging. The global mean tissue transit time was ∼1100 and 1400 ms for two conditions of bipolar gradients with specific encoding velocity (Venc) of 29 and 8 mm/sec, respectively. The mean tissue transit time measured within cerebral vascular territories was shortest in the deep middle cerebral artery (MCA) territory. Application of the FEAST technique in two patients with cerebrovascular disease demonstrated prolonged tissue transit times in the affected vascular territories which were consistent with results from other MR imaging modalities.",
keywords = "Arterial spin labeling (ASL), Cerebral blood flow (CBF), Flow encoding arterial spin tagging (FEAST), Functional brain imaging, Tissue transit time",
author = "Jiongjiong Wang and Alsop, {David C.} and Song, {Hee Kwon} and Maldjian, {Joseph A} and Kathy Tang and Salvucci, {Alana E.} and Detre, {John A.}",
year = "2003",
month = "9",
day = "1",
doi = "10.1002/mrm.10559",
language = "English (US)",
volume = "50",
pages = "599--607",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Arterial transit time imaging with flow encoding arterial spin tagging (FEAST)

AU - Wang, Jiongjiong

AU - Alsop, David C.

AU - Song, Hee Kwon

AU - Maldjian, Joseph A

AU - Tang, Kathy

AU - Salvucci, Alana E.

AU - Detre, John A.

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Arterial spin labeling (ASL) perfusion imaging provides direct and absolute measurement of cerebral blood flow (CBF). Arterial transit time is a related physiological parameter reflecting the duration for the labeled spins to reach the brain region of interest. Most of the existing ASL approaches to assess arterial transit time rely on multiple measurements at various postlabeling delay times, and thus are vulnerable to motion artifact as well as computational error. We describe the use of flow encoding arterial spin tagging (FEAST) technique to measure tissue transit time, which can be derived from the ratio between the ASL signals measured with and without appropriate bipolar gradients. In the present study, we provided a theoretical framework and carried out an experimental validation during steady-state imaging. The global mean tissue transit time was ∼1100 and 1400 ms for two conditions of bipolar gradients with specific encoding velocity (Venc) of 29 and 8 mm/sec, respectively. The mean tissue transit time measured within cerebral vascular territories was shortest in the deep middle cerebral artery (MCA) territory. Application of the FEAST technique in two patients with cerebrovascular disease demonstrated prolonged tissue transit times in the affected vascular territories which were consistent with results from other MR imaging modalities.

AB - Arterial spin labeling (ASL) perfusion imaging provides direct and absolute measurement of cerebral blood flow (CBF). Arterial transit time is a related physiological parameter reflecting the duration for the labeled spins to reach the brain region of interest. Most of the existing ASL approaches to assess arterial transit time rely on multiple measurements at various postlabeling delay times, and thus are vulnerable to motion artifact as well as computational error. We describe the use of flow encoding arterial spin tagging (FEAST) technique to measure tissue transit time, which can be derived from the ratio between the ASL signals measured with and without appropriate bipolar gradients. In the present study, we provided a theoretical framework and carried out an experimental validation during steady-state imaging. The global mean tissue transit time was ∼1100 and 1400 ms for two conditions of bipolar gradients with specific encoding velocity (Venc) of 29 and 8 mm/sec, respectively. The mean tissue transit time measured within cerebral vascular territories was shortest in the deep middle cerebral artery (MCA) territory. Application of the FEAST technique in two patients with cerebrovascular disease demonstrated prolonged tissue transit times in the affected vascular territories which were consistent with results from other MR imaging modalities.

KW - Arterial spin labeling (ASL)

KW - Cerebral blood flow (CBF)

KW - Flow encoding arterial spin tagging (FEAST)

KW - Functional brain imaging

KW - Tissue transit time

UR - http://www.scopus.com/inward/record.url?scp=0042839760&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042839760&partnerID=8YFLogxK

U2 - 10.1002/mrm.10559

DO - 10.1002/mrm.10559

M3 - Article

C2 - 12939768

AN - SCOPUS:0042839760

VL - 50

SP - 599

EP - 607

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 3

ER -