Assessment of aortic stiffness in patients with ankylosing spondylitis using cardiovascular magnetic resonance

P. Stefan Biesbroek, Sjoerd C. Heslinga, Peter M. van de Ven, Mike J.L. Peters, Raquel P. Amier, Thelma C. Konings, Christopher D. Maroules, Colby Ayers, Parag H. Joshi, Irene E. van der Horst-Bruinsma, Vokko P. van Halm, Albert C. van Rossum, Michael T. Nurmohamed, Robin Nijveldt

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

To evaluate aortic stiffness in patients with ankylosing spondylitis (AS) using cardiovascular magnetic resonance (CMR) and to assess its association with AS characteristics and left ventricular (LV) remodeling. In this prospective study, 14 consecutive AS patients were each matched to two controls without cardiovascular symptoms or known cardiovascular disease who underwent CMR imaging for the assessment of aortic arch pulse wave velocity (PWV) at 1.5 Tesla. To enhance comparability of the samples, matching was done with replacement resulting in 20 unique controls. Only AS patients with abnormal findings on screening echocardiography were included in this exploratory study. Cine CMR was used to assess LV geometry and systolic function, and late gadolinium enhancement was performed to determine the presence of myocardial hyperenhancement (i.e., fibrosis). Aortic arch PWV was significantly higher in the AS group compared with the control group (median 9.7 m/s, interquartile range [IQR] 7.1 to 11.8 vs. 6.1 m/s, IQR 4.6 to 7.6 m/s; p < 0.001). PWV was positively associated with functional disability as measured by BASFI (R: 0.62; p = 0.018). Three patients (21%) with a non-ischemic pattern of hyperenhancement showed increased PWV (11.7, 12.3, and 16.5 m/s) as compared to the 11 patients without hyperenhancement (9.0 m/s, IQR 6.6 to 10.5 m/s; p = 0.022). PWV was inversely associated with LV ejection fraction (R: − 0.63; p = 0.015), but was not found to be statistically correlated to LV volumes or mass. Aortic arch PWV was increased in our cohort of patients with AS. Higher PWV in the aortic arch was associated with functional disability, the presence of non-ischemic hyperenhancement, and reduced LV systolic function.

Original languageEnglish (US)
Pages (from-to)2151-2159
Number of pages9
JournalClinical Rheumatology
Volume37
Issue number8
DOIs
StatePublished - Aug 1 2018

Keywords

  • Magnetic resonance imaging
  • Pulse wave analysis
  • Spondylitis, ankylosing
  • Vascular stiffness
  • Ventricular remodeling

ASJC Scopus subject areas

  • Rheumatology

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    Biesbroek, P. S., Heslinga, S. C., van de Ven, P. M., Peters, M. J. L., Amier, R. P., Konings, T. C., Maroules, C. D., Ayers, C., Joshi, P. H., van der Horst-Bruinsma, I. E., van Halm, V. P., van Rossum, A. C., Nurmohamed, M. T., & Nijveldt, R. (2018). Assessment of aortic stiffness in patients with ankylosing spondylitis using cardiovascular magnetic resonance. Clinical Rheumatology, 37(8), 2151-2159. https://doi.org/10.1007/s10067-018-4135-x