Assessment of blood pressure control during once-a-day administration of antihypertensive drugs

C. V S Ram, R. J. Anderson, G. R. Hart, Norman M Kaplan

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The quality of blood pressure (BP) control during twice and once-a-day administration of antihypertensive drugs was evaluated in twenty-four patients with essential hypertension. They were treated over periods of several weeks with chlorthalidone and clonidine given twice a day and then received the total daily dose at once, at bedtime. BP was monitored over a 24-hour period with a semiautomatic device during both the twice- and one-daily dose, readings being taken at 7 a.m., 11 a.m., 1 p.m., 4 p.m., 7 p.m. and 10 p.m., and then compared. There was no statistically significant difference (p <0.25) in BP control between the b.i.d. and the q.d. schedule of antihypertensive therapy. It is concluded that smooth control of BP can be obtained in the treatment of mild or moderate, uncomplicated hypertension with a single daily dose of a combination of clonidine and chlorthalidone.

Original languageEnglish (US)
Pages (from-to)88-95
Number of pages8
JournalCurrent Therapeutic Research - Clinical and Experimental
Volume28
Issue number1
StatePublished - 1980

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Antihypertensive Agents
Chlorthalidone
Blood Pressure
Clonidine
Reading
Appointments and Schedules
Hypertension
Equipment and Supplies
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Assessment of blood pressure control during once-a-day administration of antihypertensive drugs. / Ram, C. V S; Anderson, R. J.; Hart, G. R.; Kaplan, Norman M.

In: Current Therapeutic Research - Clinical and Experimental, Vol. 28, No. 1, 1980, p. 88-95.

Research output: Contribution to journalArticle

Ram, C. V S ; Anderson, R. J. ; Hart, G. R. ; Kaplan, Norman M. / Assessment of blood pressure control during once-a-day administration of antihypertensive drugs. In: Current Therapeutic Research - Clinical and Experimental. 1980 ; Vol. 28, No. 1. pp. 88-95.
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