Association between arsenic exposure and a measure of subclinical sensory neuropathy in Bangladesh

Danella M. Hafeman, Habibul Ahsan, Elan D. Louis, Abu B. Siddique, Vesna Slavkovich, Zhongqi Cheng, Alexander Van Geen, Joseph H. Graziano

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Objectives: We examined the association between arsenic exposure and peripheral neuropathy in Bangladesh, where the population has been chronically exposed to arsenic in drinking water. Methods: We conducted a cross-sectional study of 137 subjects derived from a larger cohort. Exposure measures included individual water arsenic concentration, cumulative arsenic index, and urinary arsenic concentration taken at two time points (2001 and 2003). The primary outcome measurement was elevated vibrotactile threshold, as measured by a vibration sensitivity tester (Vibratron II). Results: Arsenic exposure was associated with elevated toe vibration threshold (TVT). Specifically, cumulative arsenic index and urinary arsenic (2001) were both significantly associated with elevated TVT (P = 0.02 and P = 0.009, respectively) after adjustment for age and gender. Conclusions: Increased arsenic exposure, as measured by both cumulative and urinary measures, was associated with evidence of subclinical sensory neuropathy.

Original languageEnglish (US)
Pages (from-to)778-784
Number of pages7
JournalJournal of Occupational and Environmental Medicine
Issue number8
StatePublished - Aug 2005
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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