Association between changes in suspicious prostate lesions on serial MRI examinations and follow-up biopsy results

Andrew B. Rosenkrantz, Samuel L. Rice, Natasha E. Wehrli, Fang Ming Deng, Samir S. Taneja

Research output: Contribution to journalArticlepeer-review

Abstract

We assessed changes in prostate lesions on serial magnetic resonance imaging (MRI) examinations in predicting biopsy results. Fifty-five men undergoing two prostate MRI examinations ≥. 6. months apart, followed by targeted biopsy, were included. Two radiologists assessed dominant lesions for an increase in size or suspicion score. Progression on MRI had lower sensitivity (23.5%-35.3%) and higher specificity (76.2%-90.5%) than prostate-specific antigen (PSA) velocity (sensitivity 70.6%, specificity 52.4%) for predicting positive biopsy. Highest accuracy was achieved by PSA velocity (63.6%) for positive biopsy, and by MRI (65.5%-72.7%) for Gleason >. 6 tumor. Findings support lesion progression on MRI serving as a basis for performing subsequent targeted biopsy.

Original languageEnglish (US)
Pages (from-to)264-269
Number of pages6
JournalClinical Imaging
Volume39
Issue number2
DOIs
StatePublished - Mar 1 2015
Externally publishedYes

Keywords

  • Biopsy
  • MRI
  • Prostate cancer
  • PSA

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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