TY - JOUR
T1 - Association between estimated glomerular filtration rate and clinical outcomes in patients with acute ischaemic stroke
T2 - Results from China National Stroke Registry
AU - Wang, Xianwei
AU - Wang, Yilong
AU - Wang, Chunxue
AU - Zhao, Xingquan
AU - Xian, Ying
AU - Wang, David
AU - Liu, Liping
AU - Luo, Yang
AU - Liu, Gaifen
AU - Wang, Yongjun
N1 - Publisher Copyright:
© The Author 2014.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Background: the impact of estimated glomerular filtration rate (eGFR) on stroke clinical outcomes remains controversial. We examined the association between eGFR and all-cause mortality, recurrent stroke, and stroke disability in patients with acute ischaemic stroke. Methods: we analysed 8865 patients with acute ischaemic stroke in the China National Stroke Registry (CNSR) between September 2007 and August 2008. Multivariate logistic regression analysis was used to evaluate the association between eGFR and 1-year all-cause mortality, recurrent stroke, and stroke disability. Low eGFR was defined as <45 ml/min/1.73 m2. Results: of 8865 acute ischaemic stroke patients included in the analysis, eGFR of <45 ml/min/1.73 m2 occurred in 394 (4.4%), eGFR of 45-59 ml/min/1.73 m2 in 675 (7.6%), eGFR of 60-89 ml/min/1.73 m2 in 3533 (39.9%), and eGFR of =90 ml/min/ 1.73 m2 in 4263 (48.1%) at baseline. Patients with reduced renal function were more likely to die, experience recurrent stroke or have stroke disability than patients with preserved renal function. After adjusting for both demographic and clinical risk factors, an eGFR of <45 ml/min/1.73 m2 was independently associated with 1-year all-cause mortality (OR: 2.65; 95% CI: 1.95-3.59) and recurrent stroke (OR: 1.97; 95% CI: 1.51-2.56) but not for stroke disability defined as modified Rankin Score of 2-6 (OR: 1.26; 95% CI: 0.95-1.67). These results were consistent in stratified analyses by age, diabetes or hypertension. Conclusions: a low eGFR was associated with increased risks of all-cause mortality and recurrent stroke independent of the traditional vascular risk factors in Chinese stroke patients.
AB - Background: the impact of estimated glomerular filtration rate (eGFR) on stroke clinical outcomes remains controversial. We examined the association between eGFR and all-cause mortality, recurrent stroke, and stroke disability in patients with acute ischaemic stroke. Methods: we analysed 8865 patients with acute ischaemic stroke in the China National Stroke Registry (CNSR) between September 2007 and August 2008. Multivariate logistic regression analysis was used to evaluate the association between eGFR and 1-year all-cause mortality, recurrent stroke, and stroke disability. Low eGFR was defined as <45 ml/min/1.73 m2. Results: of 8865 acute ischaemic stroke patients included in the analysis, eGFR of <45 ml/min/1.73 m2 occurred in 394 (4.4%), eGFR of 45-59 ml/min/1.73 m2 in 675 (7.6%), eGFR of 60-89 ml/min/1.73 m2 in 3533 (39.9%), and eGFR of =90 ml/min/ 1.73 m2 in 4263 (48.1%) at baseline. Patients with reduced renal function were more likely to die, experience recurrent stroke or have stroke disability than patients with preserved renal function. After adjusting for both demographic and clinical risk factors, an eGFR of <45 ml/min/1.73 m2 was independently associated with 1-year all-cause mortality (OR: 2.65; 95% CI: 1.95-3.59) and recurrent stroke (OR: 1.97; 95% CI: 1.51-2.56) but not for stroke disability defined as modified Rankin Score of 2-6 (OR: 1.26; 95% CI: 0.95-1.67). These results were consistent in stratified analyses by age, diabetes or hypertension. Conclusions: a low eGFR was associated with increased risks of all-cause mortality and recurrent stroke independent of the traditional vascular risk factors in Chinese stroke patients.
KW - Acute ischaemic stroke
KW - Epidemiology
KW - Estimated glomerular filtration rate
KW - Older people
KW - Outcome
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U2 - 10.1093/ageing/afu090
DO - 10.1093/ageing/afu090
M3 - Article
C2 - 25141853
AN - SCOPUS:84911391809
SN - 0002-0729
VL - 43
SP - 839
EP - 845
JO - Age and Ageing
JF - Age and Ageing
IS - 6
ER -