TY - JOUR
T1 - Association of demographic and health characteristics with circulating oxysterol concentrations
AU - Passarelli, Michael N.
AU - McDonald, Jeffrey G.
AU - Thompson, Bonne M.
AU - Arega, Enat A.
AU - Palys, Thomas J.
AU - Rees, Judy R.
AU - Barry, Elizabeth L.
AU - Baron, John A.
N1 - Funding Information:
On behalf of the Polyp Prevention Study Group, the authors express their appreciation to the study participants, investigators, and staff. We thank Leila A. Mott for supporting data management and Margaret R. Karagas for direction of the Center for Molecular Epidemiology and Biorepository Core at Dartmouth. Funding support: This work was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health (P20GM104416). The Vitamin D/Calcium Polyp Prevention Study was supported by the National Cancer Institute at the National Institutes of Health (R01CA098286). The laboratory at the University of Texas Southwestern Medical Center is supported by the National Heart, Lung, and Blood Institute at the National Institutes of Health (P01HL020948).
Funding Information:
Funding support: This work was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health (P20GM104416). The Vitamin D/Calcium Polyp Prevention Study was supported by the National Cancer Institute at the National Institutes of Health (R01CA098286). The laboratory at the University of Texas Southwestern Medical Center is supported by the National Heart, Lung, and Blood Institute at the National Institutes of Health (P01HL020948).
Publisher Copyright:
© 2022
PY - 2022
Y1 - 2022
N2 - Backgound: Circulating oxysterols, cholesterol metabolites with important signaling functions, are increasingly being recognized as candidate biomarkers for several diseases, but associations with demographic and health characteristics remain poorly described. Objective: This study aims to characterize associations of major circulating oxysterols with sex, age, race/ethnicity, body mass index (BMI), lifestyle factors, and use of common medications. Methods: We measured plasma concentrations of 27-hydroxycholesterol (27-OHC), 25-hydroxycholesterol (25-OHC), 24(S)-hydroxycholesterol (24(S)-OHC), 7ɑ-hydroxycholesterol (7ɑ-OHC), and 4β-hydroxycholesterol (4β-OHC) from 1,440 participants of a completed clinical trial for the chemoprevention of colorectal adenomas. Adjusted percent difference in means were calculated using linear regression. Results: Women had 18% (95% CI, 14%, 22%) lower 27-OHC and 21% (15%, 27%) higher 4β-OHC than men. Blacks had 15% (7%, 23%) higher 4β-OHC than Non-Hispanic Whites, and Asian or Pacific Islanders had 19% (2%, 35%) higher 7ɑ-OHC than Non-Hispanic Whites. Individuals of BMI ≥35 kg/m2 had 33% (25%, 41%) lower 4β-OHC than those <25 kg/m2. Current smokers had 15% (5%, 24%) higher 7ɑ-OHC than never smokers, and daily alcohol drinkers had 17% (10%, 24%) higher 7ɑ-OHC than never drinkers. Statin use was associated with lower concentrations of all 5 oxysterols. Differences in mean <15% were found for characteristics such as age, total dietary energy intake, physical activity, diabetes, and anti-inflammatory drug use. Conclusion: Circulating oxysterols are uniquely associated with multiple demographic and health characteristics.
AB - Backgound: Circulating oxysterols, cholesterol metabolites with important signaling functions, are increasingly being recognized as candidate biomarkers for several diseases, but associations with demographic and health characteristics remain poorly described. Objective: This study aims to characterize associations of major circulating oxysterols with sex, age, race/ethnicity, body mass index (BMI), lifestyle factors, and use of common medications. Methods: We measured plasma concentrations of 27-hydroxycholesterol (27-OHC), 25-hydroxycholesterol (25-OHC), 24(S)-hydroxycholesterol (24(S)-OHC), 7ɑ-hydroxycholesterol (7ɑ-OHC), and 4β-hydroxycholesterol (4β-OHC) from 1,440 participants of a completed clinical trial for the chemoprevention of colorectal adenomas. Adjusted percent difference in means were calculated using linear regression. Results: Women had 18% (95% CI, 14%, 22%) lower 27-OHC and 21% (15%, 27%) higher 4β-OHC than men. Blacks had 15% (7%, 23%) higher 4β-OHC than Non-Hispanic Whites, and Asian or Pacific Islanders had 19% (2%, 35%) higher 7ɑ-OHC than Non-Hispanic Whites. Individuals of BMI ≥35 kg/m2 had 33% (25%, 41%) lower 4β-OHC than those <25 kg/m2. Current smokers had 15% (5%, 24%) higher 7ɑ-OHC than never smokers, and daily alcohol drinkers had 17% (10%, 24%) higher 7ɑ-OHC than never drinkers. Statin use was associated with lower concentrations of all 5 oxysterols. Differences in mean <15% were found for characteristics such as age, total dietary energy intake, physical activity, diabetes, and anti-inflammatory drug use. Conclusion: Circulating oxysterols are uniquely associated with multiple demographic and health characteristics.
KW - 24(S)-hydroxycholesterol
KW - 25-hydroxycholesterol
KW - 27-hydroxycholesterol
KW - 4β-hydroxycholesterol
KW - 7ɑ-hydroxycholesterol
KW - epidemiology
KW - oxysterols
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U2 - 10.1016/j.jacl.2022.03.012
DO - 10.1016/j.jacl.2022.03.012
M3 - Article
C2 - 35461764
AN - SCOPUS:85128657655
SN - 1933-2874
JO - Journal of Clinical Lipidology
JF - Journal of Clinical Lipidology
ER -