Association of discoid lupus erythematosus with other clinical manifestations among patients with systemic lupus erythematosus

Joseph F. Merola, Stephen D. Prystowsky, Christina Iversen, Jose A. Gomez-Puerta, Tabatha Norton, Peter Tsao, Elena Massarotti, Peter Schur, Bonnie Bermas, Karen H. Costenbader

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Background: Cutaneous discoid lupus erythematosus (DLE) among patients with systemic lupus erythematosus (SLE) may be associated with less severe disease and with low frequency of nephritis and end-stage renal disease (ESRD). Objective: We sought to investigate associations between confirmed DLE and other SLE manifestations, adjusting for confounders. Methods: We identified patients with rheumatologist confirmation, according to 1997 American College of Rheumatology (ACR) SLE classification criteria, more than 2 visits, longer than 3 months of follow-up, and documented year of SLE diagnosis. DLE was confirmed by a dermatologist, supported by histopathology and images. SLE manifestations, medications, and serologies were collected. Multivariable-adjusted logistic regression analyses tested for associations between DLE and each of the ACR SLE criteria, and ESRD. Results: A total of 1043 patients with SLE (117 with DLE and 926 without DLE) were included in the study. After multivariable adjustment, DLE in SLE was significantly associated with photosensitivity (odds ratio [OR] 1.63), leukopenia (OR 1.55), and anti-Smith antibodies (OR 2.41). DLE was significantly associated with reduced risks of arthritis (OR 0.49) and pleuritis (OR 0.56). We found no significant associations between DLE and nephritis or ESRD. Limitations: Cross-sectional data collection with risk of data not captured from visits outside system was a limitation. Conclusions: In our SLE cohort, DLE was confirmed by a dermatologist and we adjusted for possible confounding by medication use, in particular hydroxychloroquine. We found increased risks of photosensitivity, leukopenia, and anti-Smith antibodies and decreased risks of pleuritis and arthritis in patients with SLE and DLE. DLE was not related to anti-double-stranded DNA antibodies, lupus nephritis, or ESRD. These findings have implications for prognosis among patients with SLE.

Original languageEnglish (US)
Pages (from-to)19-24
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume69
Issue number1
DOIs
StatePublished - Jul 2013

Keywords

  • cutaneous lupus erythematosus
  • discoid lupus erythematosus
  • epidemiology
  • prognosis
  • systemic lupus erythematosus

ASJC Scopus subject areas

  • Dermatology

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