Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring

Wolfgang Lieb, Michael J. Pencina, Thomas J. Wang, Martin G. Larson, Katherine J. Lanier, Emelia J. Benjamin, Daniel Levy, Geoffrey H. Tofler, James B. Meigs, Christopher Newton-Cheh, Ramachandran S. Vasan

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Children of parents with hypertension are at increased risk of developing high blood pressure. We hypothesize that circulating concentrations of putative biomarkers (that may play a role in development of high blood pressure) are higher in nonhypertensive offspring of parents with hypertension. We compared concentrations of 4 different biomarkers (urinary albumin:creatinine ratio, circulating C-reactive protein, aldosterone:renin ratio, and plasminogen activator inhibitor-1) in nonhypertensive Framingham offspring study participants with none (n=233), 1 (n=474), or both (n=322) parents with hypertension. Parental hypertension was defined as onset before age 60 years, based on longitudinal observations of the original Framingham cohort. Serum C-reactive protein concentrations were higher in nonhypertensive offspring with 1 (median: 1.7; Q1 to Q3: 0.8 to 3.6 mg/L) or both parents with hypertension (median: 1.8; Q1 to Q3: 0.7 to 3.6 mg/L) compared with offspring without parental hypertension (median: 1.4; Q1 to Q3: 0.7 to 3.2 mg/L). In multivariable analyses, parental hypertension was associated with higher serum C-reactive protein concentration in offspring (15% increase per parent with hypertension; P=0.004). Prospectively, the relation of parental hypertension to longitudinal changes in blood pressure in the nonhypertensive offspring was attenuated on adjustment for C-reactive protein (P=0.04 for attenuation). The levels of the other biomarkers evaluated did not significantly differ in offspring according to parental hypertension status. In conclusion, serum C-reactive protein concentrations are higher in nonhypertensive offspring of parents with hypertension. These data suggest that inflammation may partly mediate the familial influences on hypertension risk.

Original languageEnglish (US)
Pages (from-to)381-386
Number of pages6
JournalHypertension
Volume52
Issue number2
DOIs
StatePublished - Aug 1 2008
Externally publishedYes

Keywords

  • Biomarkers
  • C-reactive protein
  • Hypertension
  • Offspring

ASJC Scopus subject areas

  • Internal Medicine

Fingerprint Dive into the research topics of 'Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring'. Together they form a unique fingerprint.

  • Cite this

    Lieb, W., Pencina, M. J., Wang, T. J., Larson, M. G., Lanier, K. J., Benjamin, E. J., Levy, D., Tofler, G. H., Meigs, J. B., Newton-Cheh, C., & Vasan, R. S. (2008). Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring. Hypertension, 52(2), 381-386. https://doi.org/10.1161/HYPERTENSIONAHA.108.113589