TY - JOUR
T1 - Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis
AU - Olsen, Nancy J.
AU - Callahan, Leigh F.
AU - Brooks, Raye H.
AU - Nance, Paul
AU - Kaye, Jeremy J.
AU - Stastny, Peter
AU - Pincus, Theodore
N1 - Funding Information:
From the Department of Medicine, Division of Rheumatology and Immunology, and the Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tennessee, and the Department of Medicine, Division of Transplant Immunology, University of Texas Health Science Center, Dallas, Texas. This work was supported in part by National Institutes of Health General Clinical Research Centers grant 5MOiRR-00095, NIH grant AM-21393 to the American Rheumatism Association Medical Information System, the Jack C. Massey Foundation, Robert Wood Johnson Foundation, Arthritis Foundation, and the Maury County Lupus Fund. Requests for reprints should be addressed to Dr. Nancy J. Olsen, B-3219 Medical Center North, Vanderbilt University, Nashville, Tennessee 37232. Manuscript submitted May 25, 1987, and accepted in revised form November 11, 1987. *Current address: Division of Transplant Immunology, Department of Medicine, University of Texas Health Science Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75235.
PY - 1988/2
Y1 - 1988/2
N2 - Possible associations between HLA-DR4 and laboratory, radiographic, joint count, functional, and demographic measures of clinical status were analyzed in 154 white patients with rheumatoid arthritis. Overall, 65 percent of the patients were HLA-DR4 positive, similar to other series. HLA-DR4 was associated significantly with the presence of rheumatoid factor and more severe radiographic changes. HLA-DR4 was not associated with significant differences in demographic, joint count, or functional measures of clinical status. HLA-DR1 was not associated significantly with differences in the presence of rheumatoid factor, radiographic changes, or other measures of clinical status. Selective associations of HLA-DR4 with rheumatoid factor and radiographic scores were more marked in men than in women. Patients who were putatively homozygous for HLA-DR4 were all seropositive and had more severe radiographic changes than patients who were heterozygous for HLA-DR4.
AB - Possible associations between HLA-DR4 and laboratory, radiographic, joint count, functional, and demographic measures of clinical status were analyzed in 154 white patients with rheumatoid arthritis. Overall, 65 percent of the patients were HLA-DR4 positive, similar to other series. HLA-DR4 was associated significantly with the presence of rheumatoid factor and more severe radiographic changes. HLA-DR4 was not associated with significant differences in demographic, joint count, or functional measures of clinical status. HLA-DR1 was not associated significantly with differences in the presence of rheumatoid factor, radiographic changes, or other measures of clinical status. Selective associations of HLA-DR4 with rheumatoid factor and radiographic scores were more marked in men than in women. Patients who were putatively homozygous for HLA-DR4 were all seropositive and had more severe radiographic changes than patients who were heterozygous for HLA-DR4.
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U2 - 10.1016/0002-9343(88)90422-6
DO - 10.1016/0002-9343(88)90422-6
M3 - Article
C2 - 3261537
AN - SCOPUS:0023868510
SN - 0002-9343
VL - 84
SP - 257
EP - 264
JO - The American Journal of Medicine
JF - The American Journal of Medicine
IS - 2
ER -