Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis

Nancy J. Olsen, Leigh F. Callahan, Raye H. Brooks, Paul Nance, Jeremy J. Kaye, Peter Stastny, Theodore Pincus

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Possible associations between HLA-DR4 and laboratory, radiographic, joint count, functional, and demographic measures of clinical status were analyzed in 154 white patients with rheumatoid arthritis. Overall, 65 percent of the patients were HLA-DR4 positive, similar to other series. HLA-DR4 was associated significantly with the presence of rheumatoid factor and more severe radiographic changes. HLA-DR4 was not associated with significant differences in demographic, joint count, or functional measures of clinical status. HLA-DR1 was not associated significantly with differences in the presence of rheumatoid factor, radiographic changes, or other measures of clinical status. Selective associations of HLA-DR4 with rheumatoid factor and radiographic scores were more marked in men than in women. Patients who were putatively homozygous for HLA-DR4 were all seropositive and had more severe radiographic changes than patients who were heterozygous for HLA-DR4.

Original languageEnglish (US)
Pages (from-to)257-264
Number of pages8
JournalThe American journal of medicine
Volume84
Issue number2
DOIs
StatePublished - 1988

Fingerprint

HLA-DR4 Antigen
Rheumatoid Factor
Rheumatoid Arthritis
HLA-DR1 Antigen
Joints
Demography

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Olsen, N. J., Callahan, L. F., Brooks, R. H., Nance, P., Kaye, J. J., Stastny, P., & Pincus, T. (1988). Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis. The American journal of medicine, 84(2), 257-264. https://doi.org/10.1016/0002-9343(88)90422-6

Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis. / Olsen, Nancy J.; Callahan, Leigh F.; Brooks, Raye H.; Nance, Paul; Kaye, Jeremy J.; Stastny, Peter; Pincus, Theodore.

In: The American journal of medicine, Vol. 84, No. 2, 1988, p. 257-264.

Research output: Contribution to journalArticle

Olsen, NJ, Callahan, LF, Brooks, RH, Nance, P, Kaye, JJ, Stastny, P & Pincus, T 1988, 'Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis', The American journal of medicine, vol. 84, no. 2, pp. 257-264. https://doi.org/10.1016/0002-9343(88)90422-6
Olsen, Nancy J. ; Callahan, Leigh F. ; Brooks, Raye H. ; Nance, Paul ; Kaye, Jeremy J. ; Stastny, Peter ; Pincus, Theodore. / Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis. In: The American journal of medicine. 1988 ; Vol. 84, No. 2. pp. 257-264.
@article{f4278a0f6bb647688c0fd6ccfbde813b,
title = "Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis",
abstract = "Possible associations between HLA-DR4 and laboratory, radiographic, joint count, functional, and demographic measures of clinical status were analyzed in 154 white patients with rheumatoid arthritis. Overall, 65 percent of the patients were HLA-DR4 positive, similar to other series. HLA-DR4 was associated significantly with the presence of rheumatoid factor and more severe radiographic changes. HLA-DR4 was not associated with significant differences in demographic, joint count, or functional measures of clinical status. HLA-DR1 was not associated significantly with differences in the presence of rheumatoid factor, radiographic changes, or other measures of clinical status. Selective associations of HLA-DR4 with rheumatoid factor and radiographic scores were more marked in men than in women. Patients who were putatively homozygous for HLA-DR4 were all seropositive and had more severe radiographic changes than patients who were heterozygous for HLA-DR4.",
author = "Olsen, {Nancy J.} and Callahan, {Leigh F.} and Brooks, {Raye H.} and Paul Nance and Kaye, {Jeremy J.} and Peter Stastny and Theodore Pincus",
year = "1988",
doi = "10.1016/0002-9343(88)90422-6",
language = "English (US)",
volume = "84",
pages = "257--264",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis

AU - Olsen, Nancy J.

AU - Callahan, Leigh F.

AU - Brooks, Raye H.

AU - Nance, Paul

AU - Kaye, Jeremy J.

AU - Stastny, Peter

AU - Pincus, Theodore

PY - 1988

Y1 - 1988

N2 - Possible associations between HLA-DR4 and laboratory, radiographic, joint count, functional, and demographic measures of clinical status were analyzed in 154 white patients with rheumatoid arthritis. Overall, 65 percent of the patients were HLA-DR4 positive, similar to other series. HLA-DR4 was associated significantly with the presence of rheumatoid factor and more severe radiographic changes. HLA-DR4 was not associated with significant differences in demographic, joint count, or functional measures of clinical status. HLA-DR1 was not associated significantly with differences in the presence of rheumatoid factor, radiographic changes, or other measures of clinical status. Selective associations of HLA-DR4 with rheumatoid factor and radiographic scores were more marked in men than in women. Patients who were putatively homozygous for HLA-DR4 were all seropositive and had more severe radiographic changes than patients who were heterozygous for HLA-DR4.

AB - Possible associations between HLA-DR4 and laboratory, radiographic, joint count, functional, and demographic measures of clinical status were analyzed in 154 white patients with rheumatoid arthritis. Overall, 65 percent of the patients were HLA-DR4 positive, similar to other series. HLA-DR4 was associated significantly with the presence of rheumatoid factor and more severe radiographic changes. HLA-DR4 was not associated with significant differences in demographic, joint count, or functional measures of clinical status. HLA-DR1 was not associated significantly with differences in the presence of rheumatoid factor, radiographic changes, or other measures of clinical status. Selective associations of HLA-DR4 with rheumatoid factor and radiographic scores were more marked in men than in women. Patients who were putatively homozygous for HLA-DR4 were all seropositive and had more severe radiographic changes than patients who were heterozygous for HLA-DR4.

UR - http://www.scopus.com/inward/record.url?scp=0023868510&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023868510&partnerID=8YFLogxK

U2 - 10.1016/0002-9343(88)90422-6

DO - 10.1016/0002-9343(88)90422-6

M3 - Article

VL - 84

SP - 257

EP - 264

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

IS - 2

ER -