TY - JOUR
T1 - Associations of serum cytokines and chemokines with the risk of incident cancer in a prospective rheumatoid arthritis cohort
AU - England, Bryant R.
AU - Campany, Megan
AU - Sayles, Harlan
AU - Roul, Punyasha
AU - Yang, Yangyuna
AU - Ganti, Apar Kishor
AU - Sokolove, Jeremy
AU - Robinson, William H.
AU - Reimold, Andreas M.
AU - Kerr, Gail S.
AU - Cannon, Grant W.
AU - Sauer, Brian C.
AU - Baker, Joshua F.
AU - Thiele, Geoffrey M.
AU - Mikuls, Ted R.
N1 - Publisher Copyright:
© 2021
PY - 2021/8
Y1 - 2021/8
N2 - Objectives: We aimed to assess whether serum cytokine/chemokine concentrations predict incident cancer in RA patients. Methods: Data from cancer-free enrollees in the Veterans Affairs Rheumatoid Arthritis (VARA) Registry were linked to a national VA oncology database and the National Death Index (NDI) to identify incident cancers. Seventeen serum cytokines/chemokines were measured from enrollment serum and an overall weighted cytokine/chemokine score (CK score) was calculated. Associations of cytokines/chemokines with all-site, lung, and lymphoproliferative cancers were assessed in Cox regression models accounting for relevant covariates including age, sex, RA disease activity, and smoking. Results: In 1216 patients, 146 incident cancers (42 lung and 23 lymphoproliferative cancers) occurred over 10,072 patient-years of follow-up with a median time of 4.6 years from enrollment (cytokine/chemokine measurement) to cancer incidence. In fully adjusted models, CK score was associated with a higher risk of all-site (aHR 1.32, 95% CI 1.01–1.71, p < 0.001), lung (aHR 1.81, 1.40–2.34, p = 0.001), and lung/lymphoproliferative (aHR 1.54 [1.35–1.75], p < 0.001) cancer. The highest quartile of CK score was associated with a higher risk of all-site (aHR 1.91, 0.96–3.81, p = 0.07; p-trend = 0.005), lung (aHR 8.18, 1.63–41.23, p = 0.01; p-trend < 0.001), and lung/lymphoproliferative (aHR 4.56 [1.84–11.31], p = 0.001; p-trend < 0.001) cancer. Thirteen of 17 individual analytes were associated with incident cancer risk. Conclusion: Elevated cytokine/chemokine concentrations are predictive of future cancer in RA patients, particularly lung and lymphoproliferative cancers. These results suggest that the measurement of circulating cytokines/chemokines could be informative in cancer risk stratification and could provide insight into future cancer prevention strategies in RA, and possibly individuals without RA.
AB - Objectives: We aimed to assess whether serum cytokine/chemokine concentrations predict incident cancer in RA patients. Methods: Data from cancer-free enrollees in the Veterans Affairs Rheumatoid Arthritis (VARA) Registry were linked to a national VA oncology database and the National Death Index (NDI) to identify incident cancers. Seventeen serum cytokines/chemokines were measured from enrollment serum and an overall weighted cytokine/chemokine score (CK score) was calculated. Associations of cytokines/chemokines with all-site, lung, and lymphoproliferative cancers were assessed in Cox regression models accounting for relevant covariates including age, sex, RA disease activity, and smoking. Results: In 1216 patients, 146 incident cancers (42 lung and 23 lymphoproliferative cancers) occurred over 10,072 patient-years of follow-up with a median time of 4.6 years from enrollment (cytokine/chemokine measurement) to cancer incidence. In fully adjusted models, CK score was associated with a higher risk of all-site (aHR 1.32, 95% CI 1.01–1.71, p < 0.001), lung (aHR 1.81, 1.40–2.34, p = 0.001), and lung/lymphoproliferative (aHR 1.54 [1.35–1.75], p < 0.001) cancer. The highest quartile of CK score was associated with a higher risk of all-site (aHR 1.91, 0.96–3.81, p = 0.07; p-trend = 0.005), lung (aHR 8.18, 1.63–41.23, p = 0.01; p-trend < 0.001), and lung/lymphoproliferative (aHR 4.56 [1.84–11.31], p = 0.001; p-trend < 0.001) cancer. Thirteen of 17 individual analytes were associated with incident cancer risk. Conclusion: Elevated cytokine/chemokine concentrations are predictive of future cancer in RA patients, particularly lung and lymphoproliferative cancers. These results suggest that the measurement of circulating cytokines/chemokines could be informative in cancer risk stratification and could provide insight into future cancer prevention strategies in RA, and possibly individuals without RA.
KW - Biomarkers
KW - Cancer
KW - Chemokines
KW - Cytokines
KW - Lung cancer
KW - Rheumatoid arthritis
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U2 - 10.1016/j.intimp.2021.107719
DO - 10.1016/j.intimp.2021.107719
M3 - Article
C2 - 33933845
AN - SCOPUS:85105832188
SN - 1567-5769
VL - 97
JO - International Immunopharmacology
JF - International Immunopharmacology
M1 - 107719
ER -