Atherosclerosis: Lessons from LXR and the intestine

Barbara Bonamassa, Antonio Moschetta

Research output: Contribution to journalReview article

44 Scopus citations

Abstract

Modulation of the cholesterol-sensing liver X receptors (LXRs) and their downstream targets has emerged as promising therapeutic avenues in atherosclerosis. The intestine is important for its unique capabilities to act as a gatekeeper for cholesterol absorption and to participate in the process of cholesterol elimination in the feces and reverse cholesterol transport (RCT). Pharmacological and genetic intestine-specific LXR activation have been shown to protect against atherosclerosis. In this review we discuss the LXR-targeted molecular players in the enterocytes as well as the intestine-driven pathways contributing to cholesterol homeostasis with therapeutic potential as targets in the prevention and treatment of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)120-128
Number of pages9
JournalTrends in Endocrinology and Metabolism
Volume24
Issue number3
DOIs
StatePublished - Mar 1 2013

Keywords

  • Atherosclerosis
  • High-density lipoprotein (HDL)
  • Intestine
  • Liver X receptors (LXRs)
  • Reverse cholesterol transport (RCT)

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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