Atherosclerosis: Lessons from LXR and the intestine

Barbara Bonamassa; Antonio Moschetta

doi:10.1016/j.tem.2012.10.004

Atherosclerosis: Lessons from LXR and the intestine

Barbara Bonamassa, Antonio Moschetta

Pharmacology

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

Modulation of the cholesterol-sensing liver X receptors (LXRs) and their downstream targets has emerged as promising therapeutic avenues in atherosclerosis. The intestine is important for its unique capabilities to act as a gatekeeper for cholesterol absorption and to participate in the process of cholesterol elimination in the feces and reverse cholesterol transport (RCT). Pharmacological and genetic intestine-specific LXR activation have been shown to protect against atherosclerosis. In this review we discuss the LXR-targeted molecular players in the enterocytes as well as the intestine-driven pathways contributing to cholesterol homeostasis with therapeutic potential as targets in the prevention and treatment of atherosclerosis.

Original language	English (US)
Pages (from-to)	120-128
Number of pages	9
Journal	Trends in Endocrinology and Metabolism
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/j.tem.2012.10.004
State	Published - Mar 2013

Keywords

Atherosclerosis
High-density lipoprotein (HDL)
Intestine
Liver X receptors (LXRs)
Reverse cholesterol transport (RCT)

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

Access to Document

10.1016/j.tem.2012.10.004

Cite this

@article{b4a3e15c1b2549bca75da3ea4973c3b8,

title = "Atherosclerosis: Lessons from LXR and the intestine",

abstract = "Modulation of the cholesterol-sensing liver X receptors (LXRs) and their downstream targets has emerged as promising therapeutic avenues in atherosclerosis. The intestine is important for its unique capabilities to act as a gatekeeper for cholesterol absorption and to participate in the process of cholesterol elimination in the feces and reverse cholesterol transport (RCT). Pharmacological and genetic intestine-specific LXR activation have been shown to protect against atherosclerosis. In this review we discuss the LXR-targeted molecular players in the enterocytes as well as the intestine-driven pathways contributing to cholesterol homeostasis with therapeutic potential as targets in the prevention and treatment of atherosclerosis.",

keywords = "Atherosclerosis, High-density lipoprotein (HDL), Intestine, Liver X receptors (LXRs), Reverse cholesterol transport (RCT)",

author = "Barbara Bonamassa and Antonio Moschetta",

note = "Funding Information: A.M. is funded by Italian Association for Cancer Research (AIRC, Milan, Italy, IG 10416), Italian Ministry of Health and Education (Finanziamenti per la Ricerca di Base IDEAS RBID08C9N7), Italian Ministry of Health (Young Researchers Grant 2008, GR-2008-1143546), the European Commission 7th Framework Programme FP7/2007–2013 under Grant Agreement No. 202272 (LipidomicNet), Cariplo Foundation Milan, University of Bari, Italy (ORBA 08WEZJ, 07X7Q1, 06BXVC, IDEA GRBA0802SJ). B.B. is a fellow of the Italian Foundation for Cancer Research (FIRC) (Milan, Italy). We thank Roberta Le Donne for artwork.",

year = "2013",

month = mar,

doi = "10.1016/j.tem.2012.10.004",

language = "English (US)",

volume = "24",

pages = "120--128",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Atherosclerosis

T2 - Lessons from LXR and the intestine

AU - Bonamassa, Barbara

AU - Moschetta, Antonio

N1 - Funding Information: A.M. is funded by Italian Association for Cancer Research (AIRC, Milan, Italy, IG 10416), Italian Ministry of Health and Education (Finanziamenti per la Ricerca di Base IDEAS RBID08C9N7), Italian Ministry of Health (Young Researchers Grant 2008, GR-2008-1143546), the European Commission 7th Framework Programme FP7/2007–2013 under Grant Agreement No. 202272 (LipidomicNet), Cariplo Foundation Milan, University of Bari, Italy (ORBA 08WEZJ, 07X7Q1, 06BXVC, IDEA GRBA0802SJ). B.B. is a fellow of the Italian Foundation for Cancer Research (FIRC) (Milan, Italy). We thank Roberta Le Donne for artwork.

PY - 2013/3

Y1 - 2013/3

N2 - Modulation of the cholesterol-sensing liver X receptors (LXRs) and their downstream targets has emerged as promising therapeutic avenues in atherosclerosis. The intestine is important for its unique capabilities to act as a gatekeeper for cholesterol absorption and to participate in the process of cholesterol elimination in the feces and reverse cholesterol transport (RCT). Pharmacological and genetic intestine-specific LXR activation have been shown to protect against atherosclerosis. In this review we discuss the LXR-targeted molecular players in the enterocytes as well as the intestine-driven pathways contributing to cholesterol homeostasis with therapeutic potential as targets in the prevention and treatment of atherosclerosis.

AB - Modulation of the cholesterol-sensing liver X receptors (LXRs) and their downstream targets has emerged as promising therapeutic avenues in atherosclerosis. The intestine is important for its unique capabilities to act as a gatekeeper for cholesterol absorption and to participate in the process of cholesterol elimination in the feces and reverse cholesterol transport (RCT). Pharmacological and genetic intestine-specific LXR activation have been shown to protect against atherosclerosis. In this review we discuss the LXR-targeted molecular players in the enterocytes as well as the intestine-driven pathways contributing to cholesterol homeostasis with therapeutic potential as targets in the prevention and treatment of atherosclerosis.

KW - Atherosclerosis

KW - High-density lipoprotein (HDL)

KW - Intestine

KW - Liver X receptors (LXRs)

KW - Reverse cholesterol transport (RCT)

UR - http://www.scopus.com/inward/record.url?scp=84875260304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875260304&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2012.10.004

DO - 10.1016/j.tem.2012.10.004

M3 - Review article

C2 - 23158108

AN - SCOPUS:84875260304

SN - 1043-2760

VL - 24

SP - 120

EP - 128

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 3

ER -

Atherosclerosis: Lessons from LXR and the intestine

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this