Atpenins, new antifungal antibiotics produced by penicillium sp. Production, isolation, physico-chemical and biological properties

S. Omura, H. Tomoda, K. Kimura, D. Z. Zhen, H. Kumagai, K. Igarashi, N. Imamura, Y. Takahashi, Y. Tanaka, Y. Iwai

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Abstract

Penidllium sp. FO-125, a soil isolate, was found to produce a new antifungal antibiotic complex named atpenin. Three components A4, A5 and B were isolated from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and HPLC. The molecular formula of atpenins A4, A5 and B were determined to be C15H22NO5Cl, C15H21NO5Cl2 and C15H23NO5, respectively, on the basis of high resolution electron impact mass spectrometry and elemental analysis. They are active against filamentous fungi, especially, Trichophyton sp.

Original languageEnglish (US)
Pages (from-to)1769-1773
Number of pages5
JournalThe Journal of Antibiotics
Volume41
Issue number12
DOIs
StatePublished - Jan 1 1988

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ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Omura, S., Tomoda, H., Kimura, K., Zhen, D. Z., Kumagai, H., Igarashi, K., Imamura, N., Takahashi, Y., Tanaka, Y., & Iwai, Y. (1988). Atpenins, new antifungal antibiotics produced by penicillium sp. Production, isolation, physico-chemical and biological properties. The Journal of Antibiotics, 41(12), 1769-1773. https://doi.org/10.7164/antibiotics.41.1769