Atrial natriuretic factor inhibits maximal tubuloglomerular feedback response

C. L. Huang, M. G. Cogan

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Citations (Scopus)

Abstract

The effect of atrial natriuretic factor (ANF) on maximal tubuloglomerular feedback was assessed in 16 Munich-Wistar rats. When the loop of Henle was not perfused, ANF increased single nephron glomerular filtration rate (SNGFR) and stop-flow pressure (SFP) from 32 ± 2 nl/min and 32 ± 2 mmHg in the control period to 37 ± 2 nl/min (P < 0.05) and 40 ± 2 mmHg (p < 0.025) after ANF administration, respectively. Because ANF caused SFP to rise but did not significantly alter plasma protein concentration, the estimated glomerular capillary hydraulic pressure increased. Maximal tubuloglomerular feedback response (examined by increasing orthograde microperfusion of the loop from 0 to 50 nl/min) was significantly inhibited by ANF; changes in SNGFR and SFP during the control state, -9 ± 2 nl/min and -9 ± 1 mmHg, were reduced to -4 ± 2 nl/min (P < 0.05) and -5 ± 1 mmHg (P < 0.05), respectively, after ANF administration. In conclusion, the increase in SNGFR caused by ANF is associated with an increase in glomerular capillary hydraulic pressure and with a blunted maximal tubuloglomerular feedback response.

Original languageEnglish (US)
Title of host publicationAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume252
Edition5
StatePublished - 1987

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Atrial Natriuretic Factor
Nephrons
Pressure
Glomerular Filtration Rate
Loop of Henle
Wistar Rats
Blood Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Huang, C. L., & Cogan, M. G. (1987). Atrial natriuretic factor inhibits maximal tubuloglomerular feedback response. In American Journal of Physiology - Renal Fluid and Electrolyte Physiology (5 ed., Vol. 252)

Atrial natriuretic factor inhibits maximal tubuloglomerular feedback response. / Huang, C. L.; Cogan, M. G.

American Journal of Physiology - Renal Fluid and Electrolyte Physiology. Vol. 252 5. ed. 1987.

Research output: Chapter in Book/Report/Conference proceedingChapter

Huang, CL & Cogan, MG 1987, Atrial natriuretic factor inhibits maximal tubuloglomerular feedback response. in American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 5 edn, vol. 252.
Huang CL, Cogan MG. Atrial natriuretic factor inhibits maximal tubuloglomerular feedback response. In American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 5 ed. Vol. 252. 1987
Huang, C. L. ; Cogan, M. G. / Atrial natriuretic factor inhibits maximal tubuloglomerular feedback response. American Journal of Physiology - Renal Fluid and Electrolyte Physiology. Vol. 252 5. ed. 1987.
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