Automatic mask generation using independent component analysis in dynamic contrast enhanced-MRI

Hatef Mehrabian, Ian Pang, Chaitanya Chandrana, Rajiv Chopra, Anne L. Martel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

Studying image intensity change in each pixel in dynamic contrast enhanced (DCE)-MRI data enables differentiation of different tissue types based on their difference in contrast uptake. Pharmacokinetic modeling of tissues is commonly used to extract physiological parameters (i.e. Ktrans and v e) from the intensity-time curves. In a two compartmental model the intensity-time curve of the feeding blood vessels or arterial input function (AIF) as well as the signal from extravascular space (ES) is required. As direct measurement of these quantities is not possible some assumptions are made to approximate their values. Any error in measuring these quantities results in an error in the measured physiological parameters. We propose using Independent component analysis (ICA) to generate an automatic mask for separating the two spaces and extracting their intensity-time curves. An experimental phantom is constructed to mimic the behavior of real tissues and the actual intensity-time curves for the AIF and ES are measured from its DCE-MRI images. Then ICA is applied to the DCE dataset to separate these spaces. The result show high degree of agreement between the actual and ICA results.

Original languageEnglish (US)
Title of host publication2011 8th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI'11
Pages1657-1661
Number of pages5
DOIs
StatePublished - Nov 2 2011
Event2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11 - Chicago, IL, United States
Duration: Mar 30 2011Apr 2 2011

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11
CountryUnited States
CityChicago, IL
Period3/30/114/2/11

Keywords

  • Dynamic Contrast Enhanced-MRI
  • Independent Component Analysis
  • Pharmacokinetic modeling

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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