Autophagosome–lysosome fusion: PIs to the rescue

Linsen Li; Qing Zhong

doi:10.15252/embj.201695134

Autophagosome–lysosome fusion: PIs to the rescue

Linsen Li, Qing Zhong

Research output: Contribution to journal › Comment/debate › peer-review

6 Scopus citations

Abstract

Phosphoinositides (PIs), a small fraction of the cellular lipids, function in almost all cellular physiological processes and especially in intracellular membrane trafficking events. PIs play a critical role in autophagy, but only PI(3)P is well studied. In this issue of The EMBO Journal, Hasegawa et al (2016) identified INPP5E, an inositol polyphosphate 5-phosphatase, as a novel regulator of autophagy. INPP5E controls the level of PI(3,5)P₂ at the lysosome and thereby locally regulates the actin cytoskeleton and autophagosome–lysosome fusion.

Original language	English (US)
Pages (from-to)	1845-1847
Number of pages	3
Journal	EMBO Journal
Volume	35
Issue number	17
DOIs	https://doi.org/10.15252/embj.201695134
State	Published - Sep 1 2016

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

Access to Document

10.15252/embj.201695134

Cite this

@article{3d27e92b30a5490682e41c182e697e3e,

title = "Autophagosome–lysosome fusion: PIs to the rescue",

abstract = "Phosphoinositides (PIs), a small fraction of the cellular lipids, function in almost all cellular physiological processes and especially in intracellular membrane trafficking events. PIs play a critical role in autophagy, but only PI(3)P is well studied. In this issue of The EMBO Journal, Hasegawa et al (2016) identified INPP5E, an inositol polyphosphate 5-phosphatase, as a novel regulator of autophagy. INPP5E controls the level of PI(3,5)P2 at the lysosome and thereby locally regulates the actin cytoskeleton and autophagosome–lysosome fusion.",

author = "Linsen Li and Qing Zhong",

note = "Publisher Copyright: {\textcopyright} 2016 The Authors",

year = "2016",

month = sep,

day = "1",

doi = "10.15252/embj.201695134",

language = "English (US)",

volume = "35",

pages = "1845--1847",

journal = "EMBO Journal",

issn = "0261-4189",

publisher = "Nature Publishing Group",

number = "17",

}

TY - JOUR

T1 - Autophagosome–lysosome fusion

T2 - PIs to the rescue

AU - Li, Linsen

AU - Zhong, Qing

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Phosphoinositides (PIs), a small fraction of the cellular lipids, function in almost all cellular physiological processes and especially in intracellular membrane trafficking events. PIs play a critical role in autophagy, but only PI(3)P is well studied. In this issue of The EMBO Journal, Hasegawa et al (2016) identified INPP5E, an inositol polyphosphate 5-phosphatase, as a novel regulator of autophagy. INPP5E controls the level of PI(3,5)P2 at the lysosome and thereby locally regulates the actin cytoskeleton and autophagosome–lysosome fusion.

AB - Phosphoinositides (PIs), a small fraction of the cellular lipids, function in almost all cellular physiological processes and especially in intracellular membrane trafficking events. PIs play a critical role in autophagy, but only PI(3)P is well studied. In this issue of The EMBO Journal, Hasegawa et al (2016) identified INPP5E, an inositol polyphosphate 5-phosphatase, as a novel regulator of autophagy. INPP5E controls the level of PI(3,5)P2 at the lysosome and thereby locally regulates the actin cytoskeleton and autophagosome–lysosome fusion.

UR - http://www.scopus.com/inward/record.url?scp=84984865389&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84984865389&partnerID=8YFLogxK

U2 - 10.15252/embj.201695134

DO - 10.15252/embj.201695134

M3 - Comment/debate

C2 - 27440401

AN - SCOPUS:84984865389

SN - 0261-4189

VL - 35

SP - 1845

EP - 1847

JO - EMBO Journal

JF - EMBO Journal

IS - 17

ER -

Autophagosome–lysosome fusion: PIs to the rescue

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this