Abstract
Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for cellular homeostasis and adaption to stress. Accumulating evidence indicates that autophagy declines with age and that impaired autophagy predisposes individuals to age-related diseases, whereas interventions that stimulate autophagy often promote longevity. In this Review, we examine how the autophagy pathway restricts cellular damage and degeneration, and the impact of these functions towards tissue health and organismal lifespan.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1338-1348 |
| Number of pages | 11 |
| Journal | Nature Cell Biology |
| Volume | 20 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2018 |
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ASJC Scopus subject areas
- Cell Biology
Cite this
Autophagy and the cell biology of age-related disease. / Leidal, Andrew M.; Levine, Beth; Debnath, Jayanta.
In: Nature Cell Biology, Vol. 20, No. 12, 01.12.2018, p. 1338-1348.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Autophagy and the cell biology of age-related disease
AU - Leidal, Andrew M.
AU - Levine, Beth
AU - Debnath, Jayanta
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for cellular homeostasis and adaption to stress. Accumulating evidence indicates that autophagy declines with age and that impaired autophagy predisposes individuals to age-related diseases, whereas interventions that stimulate autophagy often promote longevity. In this Review, we examine how the autophagy pathway restricts cellular damage and degeneration, and the impact of these functions towards tissue health and organismal lifespan.
AB - Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for cellular homeostasis and adaption to stress. Accumulating evidence indicates that autophagy declines with age and that impaired autophagy predisposes individuals to age-related diseases, whereas interventions that stimulate autophagy often promote longevity. In this Review, we examine how the autophagy pathway restricts cellular damage and degeneration, and the impact of these functions towards tissue health and organismal lifespan.
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U2 - 10.1038/s41556-018-0235-8
DO - 10.1038/s41556-018-0235-8
M3 - Review article
C2 - 30482941
AN - SCOPUS:85057236648
VL - 20
SP - 1338
EP - 1348
JO - Nature Cell Biology
JF - Nature Cell Biology
SN - 1465-7392
IS - 12
ER -