Autophagy and the cell biology of age-related disease

Andrew M. Leidal; Beth Levine; Jayanta Debnath

doi:10.1038/s41556-018-0235-8

Autophagy and the cell biology of age-related disease

Andrew M. Leidal, Beth Levine, Jayanta Debnath

Research output: Contribution to journal › Review article

66 Scopus citations

Abstract

Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for cellular homeostasis and adaption to stress. Accumulating evidence indicates that autophagy declines with age and that impaired autophagy predisposes individuals to age-related diseases, whereas interventions that stimulate autophagy often promote longevity. In this Review, we examine how the autophagy pathway restricts cellular damage and degeneration, and the impact of these functions towards tissue health and organismal lifespan.

Original language	English (US)
Pages (from-to)	1338-1348
Number of pages	11
Journal	Nature Cell Biology
Volume	20
Issue number	12
DOIs	https://doi.org/10.1038/s41556-018-0235-8
State	Published - Dec 1 2018

ASJC Scopus subject areas

Cell Biology

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Leidal, A. M., Levine, B., & Debnath, J. (2018). Autophagy and the cell biology of age-related disease. Nature Cell Biology, 20(12), 1338-1348. https://doi.org/10.1038/s41556-018-0235-8

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