Autophagy balances inflammation in innate immunity

Vojo Deretic, Beth Levine

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

Macroautophagy/autophagy is a homeostatic process with multiple effects on immunity. One of the pivotal contributions of autophagy in immunity is the cell autonomous control of inflammation. This property leads to systemic consequences and thereby influences the development of innate and adaptive immunity, which promotes or suppresses pathology in various disease contexts. In this review we focus on the intersections between autophagy and inflammasome activation, autophagy and interferons, and autophagy and inflammation in association with infection.

Original languageEnglish (US)
Pages (from-to)243-251
Number of pages9
JournalAutophagy
Volume14
Issue number2
DOIs
StatePublished - Feb 1 2018

Fingerprint

Autophagy
Innate Immunity
Inflammation
Immunity
Inflammasomes
Adaptive Immunity
Interferons
Pathology
Infection

Keywords

  • Autophagy
  • inflamamsome
  • interferon
  • lysosome
  • microbes mitochondria
  • phagosome

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Autophagy balances inflammation in innate immunity. / Deretic, Vojo; Levine, Beth.

In: Autophagy, Vol. 14, No. 2, 01.02.2018, p. 243-251.

Research output: Contribution to journalReview article

Deretic, Vojo ; Levine, Beth. / Autophagy balances inflammation in innate immunity. In: Autophagy. 2018 ; Vol. 14, No. 2. pp. 243-251.
@article{a0de0cee730c452d8031618675c75f67,
title = "Autophagy balances inflammation in innate immunity",
abstract = "Macroautophagy/autophagy is a homeostatic process with multiple effects on immunity. One of the pivotal contributions of autophagy in immunity is the cell autonomous control of inflammation. This property leads to systemic consequences and thereby influences the development of innate and adaptive immunity, which promotes or suppresses pathology in various disease contexts. In this review we focus on the intersections between autophagy and inflammasome activation, autophagy and interferons, and autophagy and inflammation in association with infection.",
keywords = "Autophagy, inflamamsome, interferon, lysosome, microbes mitochondria, phagosome",
author = "Vojo Deretic and Beth Levine",
year = "2018",
month = "2",
day = "1",
doi = "10.1080/15548627.2017.1402992",
language = "English (US)",
volume = "14",
pages = "243--251",
journal = "Autophagy",
issn = "1554-8627",
publisher = "Landes Bioscience",
number = "2",

}

TY - JOUR

T1 - Autophagy balances inflammation in innate immunity

AU - Deretic, Vojo

AU - Levine, Beth

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Macroautophagy/autophagy is a homeostatic process with multiple effects on immunity. One of the pivotal contributions of autophagy in immunity is the cell autonomous control of inflammation. This property leads to systemic consequences and thereby influences the development of innate and adaptive immunity, which promotes or suppresses pathology in various disease contexts. In this review we focus on the intersections between autophagy and inflammasome activation, autophagy and interferons, and autophagy and inflammation in association with infection.

AB - Macroautophagy/autophagy is a homeostatic process with multiple effects on immunity. One of the pivotal contributions of autophagy in immunity is the cell autonomous control of inflammation. This property leads to systemic consequences and thereby influences the development of innate and adaptive immunity, which promotes or suppresses pathology in various disease contexts. In this review we focus on the intersections between autophagy and inflammasome activation, autophagy and interferons, and autophagy and inflammation in association with infection.

KW - Autophagy

KW - inflamamsome

KW - interferon

KW - lysosome

KW - microbes mitochondria

KW - phagosome

UR - http://www.scopus.com/inward/record.url?scp=85044930412&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044930412&partnerID=8YFLogxK

U2 - 10.1080/15548627.2017.1402992

DO - 10.1080/15548627.2017.1402992

M3 - Review article

C2 - 29165043

AN - SCOPUS:85044930412

VL - 14

SP - 243

EP - 251

JO - Autophagy

JF - Autophagy

SN - 1554-8627

IS - 2

ER -