Autophagy balances inflammation in innate immunity

Vojo Deretic, Beth Levine

Research output: Contribution to journalReview article

93 Scopus citations

Abstract

Macroautophagy/autophagy is a homeostatic process with multiple effects on immunity. One of the pivotal contributions of autophagy in immunity is the cell autonomous control of inflammation. This property leads to systemic consequences and thereby influences the development of innate and adaptive immunity, which promotes or suppresses pathology in various disease contexts. In this review we focus on the intersections between autophagy and inflammasome activation, autophagy and interferons, and autophagy and inflammation in association with infection.

Original languageEnglish (US)
Pages (from-to)243-251
Number of pages9
JournalAutophagy
Volume14
Issue number2
DOIs
StatePublished - Feb 1 2018

Keywords

  • Autophagy
  • inflamamsome
  • interferon
  • lysosome
  • microbes mitochondria
  • phagosome

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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