Autophagy in C. elegans.

Alicia Meléndez, Beth Levine

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Autophagy is a ubiquitous cellular process responsible for the bulk degradation of cytoplasmic components through an autophagosomal-lysosomal pathway. Genetic screens, primarily in S. cerevisiae, have identified numerous genes that are essential for autophagy. Many of these genes have orthologs in higher eukaryotes, including C. elegans, Drosophila, and mammals. Gene knockdown/knockout studies in C. elegans have been useful to probe the functions of autophagy in an intact multicellular organism that undergoes development to produce different cell types. This review summarizes important themes that have emerged regarding the roles of autophagy in C. elegans in adaptation to stress, aging, normal reproductive growth, cell death, cell growth control, neural synaptic clustering, and the degradation of aggregate-prone proteins.

Original languageEnglish (US)
Pages (from-to)1-26
Number of pages26
JournalWormBook : the online review of C. elegans biology
StatePublished - 2009

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Autophagy
Gene Knockdown Techniques
Gene Knockout Techniques
Essential Genes
Growth
Eukaryota
Drosophila
Cluster Analysis
Saccharomyces cerevisiae
Mammals
Cell Death
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Autophagy in C. elegans. / Meléndez, Alicia; Levine, Beth.

In: WormBook : the online review of C. elegans biology, 2009, p. 1-26.

Research output: Contribution to journalArticle

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