Autophagy regulates programmed cell death during the plant innate immune response

Yule Liu, Michael Schiff, Kirk Czymmek, Zsolt Tallóczy, Beth Levine, S. P. Dinesh-Kumar

Research output: Contribution to journalArticle

560 Citations (Scopus)

Abstract

The plant innate immune response includes the hypersensitive response (HR), a form of programmed cell death (PCD). PCD must be restricted to infection sites to prevent the HR from playing a pathologic rather than protective role. Here we show that plant BECLIN 1, an ortholog of the yeast and mammalian autophagy gene ATG6/VPS30/beclin 1, functions to restrict HR PCD to infection sites. Initiation of HR PCD is normal in BECLIN 1-deficient plants, but remarkably, healthy uninfected tissue adjacent to HR lesions and leaves distal to the inoculated leaf undergo unrestricted PCD. In the HR PCD response, autophagy is induced in both pathogen-infected cells and distal uninfected cells; this is reduced in BECLIN 1-deficient plants. The restriction of HR PCD also requires orthologs of other autophagy-related genes including PI3K/VPS34, ATG3, and ATG7. Thus, the evolutionarily conserved autophagy pathway plays an essential role in plant innate immunity and negatively regulates PCD.

Original languageEnglish (US)
Pages (from-to)567-577
Number of pages11
JournalCell
Volume121
Issue number4
DOIs
StatePublished - May 20 2005

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Plant Immunity
Autophagy
Cell death
Innate Immunity
Cell Death
Genes
Pathogens
Infection
Phosphatidylinositol 3-Kinases
Yeast
Yeasts
Tissue

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Liu, Y., Schiff, M., Czymmek, K., Tallóczy, Z., Levine, B., & Dinesh-Kumar, S. P. (2005). Autophagy regulates programmed cell death during the plant innate immune response. Cell, 121(4), 567-577. https://doi.org/10.1016/j.cell.2005.03.007

Autophagy regulates programmed cell death during the plant innate immune response. / Liu, Yule; Schiff, Michael; Czymmek, Kirk; Tallóczy, Zsolt; Levine, Beth; Dinesh-Kumar, S. P.

In: Cell, Vol. 121, No. 4, 20.05.2005, p. 567-577.

Research output: Contribution to journalArticle

Liu, Y, Schiff, M, Czymmek, K, Tallóczy, Z, Levine, B & Dinesh-Kumar, SP 2005, 'Autophagy regulates programmed cell death during the plant innate immune response', Cell, vol. 121, no. 4, pp. 567-577. https://doi.org/10.1016/j.cell.2005.03.007
Liu, Yule ; Schiff, Michael ; Czymmek, Kirk ; Tallóczy, Zsolt ; Levine, Beth ; Dinesh-Kumar, S. P. / Autophagy regulates programmed cell death during the plant innate immune response. In: Cell. 2005 ; Vol. 121, No. 4. pp. 567-577.
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