Bacteremia in children with sickle hemoglobin C disease and sickle beta+-thalassemia: Is prophylactic penicillin necessary?

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27 Scopus citations

Abstract

Objective: To characterize the incidence of bacteremia and its potential for progression to septicemia in children with sickle hemoglobin C disease and sickle β+-thalassemia to assess the need for penicillin prophylaxis. Study design: Retrospective chart review of the frequency and natural history of bloodstream infection in such patients not receiving prophylactic penicillin therapy and followed up in a single institution. Results: During more than 842 patient-years of observation in 242 patients with sickle hemoglobin C disease, 15 episodes of bacteremia occurred in nine patients. Septicemia was fatal in one patient. The overall incidence of bacteremia, 1.8 events per 100 patient-years (95% confidence limits: 0.8, 2.8) in patients with sickle hemoglobin C disease, was similar to that in hematologically normal children. One episode of bacteremia occurred in a patient with sickle β+-thalassemia. Conclusions: The incidence of bacteremia is not increased in young patients with sickle hemoglobin C disease and sickle β+-thalassemia. Further, unlike its course in children with sickle cell anemia, it rarely evolves into life-threatening septicemia. This probably results from the maintenance of relatively intact splenic function during infancy and early childhood in patients with sickle hemoglobin C disease and sickle β+-thalassemia. Prophylactic penicillin therapy may not be required in these patients. (J PEDIATR 1995;127:348-54).

Original languageEnglish (US)
Pages (from-to)348-354
Number of pages7
JournalThe Journal of Pediatrics
Volume127
Issue number3
DOIs
StatePublished - Sep 1995

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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