Bacterial overgrowth and intestinal atrophy in the etiology of gut barrier failure in the rat

Annabel E. Barber, William G. Jones, Joseph P. Minei, Thomas J. Fahey, Stephen F. Lowry, G. Tom Shires

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Bacterial translocation occurs in animal models of shock, trauma, sepsis, and parenteral or elemental enteral alimentation. Bowel atrophy and cecal bacterial overgrowth have both been implicated in the pathophysiology of bacterial translocation in many of these models. To further define the etiology of bacterial translocation resulting from dietary manipulations, rats were fed a elemental/defined-formula diet (DFD) for 2 weeks ad libitum and then randomized to either intestinal decontamination with a nonabsorbable antibiotic (neomycin) or no antibiotic treatment. Neomycin treatment significantly (p < 0.01) reduced the incidence of bacterial translocation after DFD, in association with a significant reduction in the number of cecal gram-negative bacteria. Neither loss of bowel mass after DFD nor bowel composition was affected by oral neomycin. Bacterial translocation after DFD would thus appear to be the result of cecal bacterial overgrowth rather than a loss of a physical intestinal barrier due to atrophy.

Original languageEnglish (US)
Pages (from-to)300-304
Number of pages5
JournalThe American Journal of Surgery
Volume161
Issue number2
DOIs
StatePublished - 1991

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Bacterial Translocation
Formulated Food
Atrophy
Neomycin
Anti-Bacterial Agents
Architectural Accessibility
Decontamination
Gram-Negative Bacteria
Small Intestine
Shock
Sepsis
Animal Models
Incidence
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery

Cite this

Bacterial overgrowth and intestinal atrophy in the etiology of gut barrier failure in the rat. / Barber, Annabel E.; Jones, William G.; Minei, Joseph P.; Fahey, Thomas J.; Lowry, Stephen F.; Shires, G. Tom.

In: The American Journal of Surgery, Vol. 161, No. 2, 1991, p. 300-304.

Research output: Contribution to journalArticle

Barber, Annabel E. ; Jones, William G. ; Minei, Joseph P. ; Fahey, Thomas J. ; Lowry, Stephen F. ; Shires, G. Tom. / Bacterial overgrowth and intestinal atrophy in the etiology of gut barrier failure in the rat. In: The American Journal of Surgery. 1991 ; Vol. 161, No. 2. pp. 300-304.
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