Bap180/Baf180 is required to maintain homeostasis of intestinal innate immune response in Drosophila and mice

Xiaomeng He, Junjing Yu, Min Wang, Yang Cheng, Yanan Han, Shuo Yang, Guizhi Shi, Lei Sun, Ying Fang, Si Tang Gong, Zhong Wang, Yang Xin Fu, Lei Pan, Hong Tang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Immune homeostasis is a prerequisite to protective immunity against gastrointestinal infections. In Drosophila, immune deficiency (IMD) signalling (tumour necrosis factor receptor/interleukin-1 receptor, TNFR/IL-1R in mammals) is indispensable for intestinal immunity against invading bacteria. However, how this local antimicrobial immune response contributes to inflammatory regulation remains poorly defined. Here, we show that flies lacking intestinal Bap180 (a subunit of the chromatin-remodelling switch/sucrose non-fermentable (SWI/SNF) complex) are susceptible to infection as a result of hyper-inflammation rather than bacterial overload. Detailed analysis shows that Bap180 is induced by the IMD-Relish response to both enteropathogenic and commensal bacteria. Upregulated Bap180 can feed back to restrain overreactive IMD signalling, as well as to repress the expression of the pro-inflammatory gene eiger (TNF), a critical step to prevent excessive tissue damage and elongate the lifespan of flies, under pathological and physiological conditions, respectively. Furthermore, intestinal targeting of Baf180 renders mice susceptible to a more aggressive infectious colitis caused by Citrobacter rodentium. Together, Bap180 and Baf180 serve as a conserved transcriptional repressor that is critical for the maintenance of innate immune homeostasis in the intestines.

Original languageEnglish (US)
Article number17056
JournalNature Microbiology
Volume2
DOIs
StatePublished - Apr 18 2017

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Innate Immunity
Diptera
Drosophila
Immunity
Citrobacter rodentium
Homeostasis
Bacteria
Chromatin Assembly and Disassembly
Interleukin-1 Receptors
Tumor Necrosis Factor Receptors
Colitis
Infection
Intestines
Sucrose
Mammals
Maintenance
Inflammation
Genes

Keywords

  • Beijing 100101
  • Cas key laboratory of infection and immunity (casklii)
  • China
  • Institute of biophysics

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Applied Microbiology and Biotechnology
  • Genetics
  • Microbiology (medical)
  • Cell Biology

Cite this

Bap180/Baf180 is required to maintain homeostasis of intestinal innate immune response in Drosophila and mice. / He, Xiaomeng; Yu, Junjing; Wang, Min; Cheng, Yang; Han, Yanan; Yang, Shuo; Shi, Guizhi; Sun, Lei; Fang, Ying; Gong, Si Tang; Wang, Zhong; Fu, Yang Xin; Pan, Lei; Tang, Hong.

In: Nature Microbiology, Vol. 2, 17056, 18.04.2017.

Research output: Contribution to journalArticle

He, X, Yu, J, Wang, M, Cheng, Y, Han, Y, Yang, S, Shi, G, Sun, L, Fang, Y, Gong, ST, Wang, Z, Fu, YX, Pan, L & Tang, H 2017, 'Bap180/Baf180 is required to maintain homeostasis of intestinal innate immune response in Drosophila and mice', Nature Microbiology, vol. 2, 17056. https://doi.org/10.1038/nmicrobiol.2017.56
He, Xiaomeng ; Yu, Junjing ; Wang, Min ; Cheng, Yang ; Han, Yanan ; Yang, Shuo ; Shi, Guizhi ; Sun, Lei ; Fang, Ying ; Gong, Si Tang ; Wang, Zhong ; Fu, Yang Xin ; Pan, Lei ; Tang, Hong. / Bap180/Baf180 is required to maintain homeostasis of intestinal innate immune response in Drosophila and mice. In: Nature Microbiology. 2017 ; Vol. 2.
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