Barrett's metaplasia and colonic neoplasms: A significant association in a 203,534-patient study

Amnon Sonnenberg, Robert M. Genta

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background and Aim: The presence of an association between Barrett's metaplasia and colonic neoplasia has remained controversial. The aim of the study was to test the presence of this association, using a large national database. Methods: From a computerized database of surgical pathology reports, we selected 203,000 subjects who underwent colonoscopy and esophago-gastro- duodenoscopy with biopsy results available from both procedures. In a case-control study we compared the occurrence of Barrett's metaplasia in patients with and without various types of colonic neoplasms. Results: Barrett's metaplasia occurred more frequently among patients with hyperplastic polyps (OR = 2.14, 95 % CI 2.02-2.27), adenomatous polyps (2.52, 2.41-2.64), advanced adenomas (2.10, 1.90-2.32), villous adenomas or adenomas with high-grade (HG) dysplasia (2.45, 2.28-2.64), and colonic adenocarcinomas (1.75, 1.39-2.22). The association between Barrett's metaplasia and colonic neoplasm applied similarly to polyps of different size, number and location within the large bowel. These types of association could also be confirmed when analyzed separately for Barrett's metaplasia characterized by low-grade or HG dysplasia, as well as esophageal adenocarcinoma. Conclusions: The data support the existence of a true association between Barrett's metaplasia and various types of colonic neoplasm. The association may be more interesting for its potential insights into the pathogenesis of the two disorders than its actual clinical implications.

Original languageEnglish (US)
Pages (from-to)2046-2051
Number of pages6
JournalDigestive Diseases and Sciences
Volume58
Issue number7
DOIs
StatePublished - Jul 2013

Fingerprint

Barrett Esophagus
Colonic Neoplasms
Polyps
Adenoma
Adenocarcinoma
Duodenoscopy
Databases
Villous Adenoma
Adenomatous Polyps
Surgical Pathology
Colonoscopy
Case-Control Studies
Biopsy
Neoplasms

Keywords

  • Barrett's esophagus
  • Colon polyps
  • Epidemiology of gastrointestinal disease
  • Gastroesophageal reflux disease
  • Helicobacter pylori

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

Barrett's metaplasia and colonic neoplasms : A significant association in a 203,534-patient study. / Sonnenberg, Amnon; Genta, Robert M.

In: Digestive Diseases and Sciences, Vol. 58, No. 7, 07.2013, p. 2046-2051.

Research output: Contribution to journalArticle

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