Basal ganglia neuronal discharge in primary and secondary dystonia in patients undergoing pallidotomy

Manjit K. Sanghera, Robert G. Grossman, Christopher G. Kalhorn, Winifred J. Hamilton, William G. Ondo, Joseph Jankovic, Giovanni Broggi, Kim J. Burchiel, Louis Whitworth, Roy A E Bakay

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

OBJECTIVE: Basal ganglia neuronal activity in patients undergoing posteroventral pallidotomy (PVP) for the treatment of primary genetic, secondary, or idiopathic dystonia (DYS) was studied to gain a better understanding of the pathophysiology of DYS. METHODS: Intraoperative neurophysiological data recorded from 15 DYS patients were compared with those from 78 patients with Parkinson's disease (PD) who underwent PVP. RESULTS: Putamen neurons in both DYS and PD patients had low discharge rates. Globus pallidus externa (GPe) and globus pallidus interna (GPi) neurons in DYS patients had significantly lower discharge rates and more irregular discharge patterns than in PD patients. GPe and GPi neurons displayed similar discharge rates and patterns in DYS, whereas in PD, the discharge rate of GPe neurons was lower than that of the GPi neurons. The discharge rate and pattern of GPe and GPi neurons in patients whose DYS was ameliorated by PVP were similar to those in DYS patients who did not benefit from PVP. No significant differences in the rate or pattern of neuronal discharge in patients with DYS of different causes were discernible. PVP was most beneficial in patients with primary genetic DYS. Anesthesia with desflurane depressed the discharge rate of the GPe and GPi neurons, particularly in patients with PD. CONCLUSION: Significant differences in the rates and patterns of discharge of GPe and GPi neurons exist in DYS and PD. The findings are discussed with reference to the current model of the functional connections of the basal ganglia.

Original languageEnglish (US)
Pages (from-to)1358-1373
Number of pages16
JournalNeurosurgery
Volume52
Issue number6
StatePublished - Jun 1 2003

Fingerprint

Pallidotomy
Dystonic Disorders
Globus Pallidus
Basal Ganglia
Dystonia
Parkinson Disease
Neurons
Patient Discharge
Putamen

Keywords

  • Dystonia
  • Electrophysiology
  • Globus pallidus externa
  • Globus pallidus interna
  • Parkinson's disease
  • Posteroventral pallidotomy
  • Putamen

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Sanghera, M. K., Grossman, R. G., Kalhorn, C. G., Hamilton, W. J., Ondo, W. G., Jankovic, J., ... Bakay, R. A. E. (2003). Basal ganglia neuronal discharge in primary and secondary dystonia in patients undergoing pallidotomy. Neurosurgery, 52(6), 1358-1373.

Basal ganglia neuronal discharge in primary and secondary dystonia in patients undergoing pallidotomy. / Sanghera, Manjit K.; Grossman, Robert G.; Kalhorn, Christopher G.; Hamilton, Winifred J.; Ondo, William G.; Jankovic, Joseph; Broggi, Giovanni; Burchiel, Kim J.; Whitworth, Louis; Bakay, Roy A E.

In: Neurosurgery, Vol. 52, No. 6, 01.06.2003, p. 1358-1373.

Research output: Contribution to journalArticle

Sanghera, MK, Grossman, RG, Kalhorn, CG, Hamilton, WJ, Ondo, WG, Jankovic, J, Broggi, G, Burchiel, KJ, Whitworth, L & Bakay, RAE 2003, 'Basal ganglia neuronal discharge in primary and secondary dystonia in patients undergoing pallidotomy', Neurosurgery, vol. 52, no. 6, pp. 1358-1373.
Sanghera MK, Grossman RG, Kalhorn CG, Hamilton WJ, Ondo WG, Jankovic J et al. Basal ganglia neuronal discharge in primary and secondary dystonia in patients undergoing pallidotomy. Neurosurgery. 2003 Jun 1;52(6):1358-1373.
Sanghera, Manjit K. ; Grossman, Robert G. ; Kalhorn, Christopher G. ; Hamilton, Winifred J. ; Ondo, William G. ; Jankovic, Joseph ; Broggi, Giovanni ; Burchiel, Kim J. ; Whitworth, Louis ; Bakay, Roy A E. / Basal ganglia neuronal discharge in primary and secondary dystonia in patients undergoing pallidotomy. In: Neurosurgery. 2003 ; Vol. 52, No. 6. pp. 1358-1373.
@article{fc990dd4583f40f682b106b138b61f33,
title = "Basal ganglia neuronal discharge in primary and secondary dystonia in patients undergoing pallidotomy",
abstract = "OBJECTIVE: Basal ganglia neuronal activity in patients undergoing posteroventral pallidotomy (PVP) for the treatment of primary genetic, secondary, or idiopathic dystonia (DYS) was studied to gain a better understanding of the pathophysiology of DYS. METHODS: Intraoperative neurophysiological data recorded from 15 DYS patients were compared with those from 78 patients with Parkinson's disease (PD) who underwent PVP. RESULTS: Putamen neurons in both DYS and PD patients had low discharge rates. Globus pallidus externa (GPe) and globus pallidus interna (GPi) neurons in DYS patients had significantly lower discharge rates and more irregular discharge patterns than in PD patients. GPe and GPi neurons displayed similar discharge rates and patterns in DYS, whereas in PD, the discharge rate of GPe neurons was lower than that of the GPi neurons. The discharge rate and pattern of GPe and GPi neurons in patients whose DYS was ameliorated by PVP were similar to those in DYS patients who did not benefit from PVP. No significant differences in the rate or pattern of neuronal discharge in patients with DYS of different causes were discernible. PVP was most beneficial in patients with primary genetic DYS. Anesthesia with desflurane depressed the discharge rate of the GPe and GPi neurons, particularly in patients with PD. CONCLUSION: Significant differences in the rates and patterns of discharge of GPe and GPi neurons exist in DYS and PD. The findings are discussed with reference to the current model of the functional connections of the basal ganglia.",
keywords = "Dystonia, Electrophysiology, Globus pallidus externa, Globus pallidus interna, Parkinson's disease, Posteroventral pallidotomy, Putamen",
author = "Sanghera, {Manjit K.} and Grossman, {Robert G.} and Kalhorn, {Christopher G.} and Hamilton, {Winifred J.} and Ondo, {William G.} and Joseph Jankovic and Giovanni Broggi and Burchiel, {Kim J.} and Louis Whitworth and Bakay, {Roy A E}",
year = "2003",
month = "6",
day = "1",
language = "English (US)",
volume = "52",
pages = "1358--1373",
journal = "Neurosurgery",
issn = "0148-396X",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Basal ganglia neuronal discharge in primary and secondary dystonia in patients undergoing pallidotomy

AU - Sanghera, Manjit K.

AU - Grossman, Robert G.

AU - Kalhorn, Christopher G.

AU - Hamilton, Winifred J.

AU - Ondo, William G.

AU - Jankovic, Joseph

AU - Broggi, Giovanni

AU - Burchiel, Kim J.

AU - Whitworth, Louis

AU - Bakay, Roy A E

PY - 2003/6/1

Y1 - 2003/6/1

N2 - OBJECTIVE: Basal ganglia neuronal activity in patients undergoing posteroventral pallidotomy (PVP) for the treatment of primary genetic, secondary, or idiopathic dystonia (DYS) was studied to gain a better understanding of the pathophysiology of DYS. METHODS: Intraoperative neurophysiological data recorded from 15 DYS patients were compared with those from 78 patients with Parkinson's disease (PD) who underwent PVP. RESULTS: Putamen neurons in both DYS and PD patients had low discharge rates. Globus pallidus externa (GPe) and globus pallidus interna (GPi) neurons in DYS patients had significantly lower discharge rates and more irregular discharge patterns than in PD patients. GPe and GPi neurons displayed similar discharge rates and patterns in DYS, whereas in PD, the discharge rate of GPe neurons was lower than that of the GPi neurons. The discharge rate and pattern of GPe and GPi neurons in patients whose DYS was ameliorated by PVP were similar to those in DYS patients who did not benefit from PVP. No significant differences in the rate or pattern of neuronal discharge in patients with DYS of different causes were discernible. PVP was most beneficial in patients with primary genetic DYS. Anesthesia with desflurane depressed the discharge rate of the GPe and GPi neurons, particularly in patients with PD. CONCLUSION: Significant differences in the rates and patterns of discharge of GPe and GPi neurons exist in DYS and PD. The findings are discussed with reference to the current model of the functional connections of the basal ganglia.

AB - OBJECTIVE: Basal ganglia neuronal activity in patients undergoing posteroventral pallidotomy (PVP) for the treatment of primary genetic, secondary, or idiopathic dystonia (DYS) was studied to gain a better understanding of the pathophysiology of DYS. METHODS: Intraoperative neurophysiological data recorded from 15 DYS patients were compared with those from 78 patients with Parkinson's disease (PD) who underwent PVP. RESULTS: Putamen neurons in both DYS and PD patients had low discharge rates. Globus pallidus externa (GPe) and globus pallidus interna (GPi) neurons in DYS patients had significantly lower discharge rates and more irregular discharge patterns than in PD patients. GPe and GPi neurons displayed similar discharge rates and patterns in DYS, whereas in PD, the discharge rate of GPe neurons was lower than that of the GPi neurons. The discharge rate and pattern of GPe and GPi neurons in patients whose DYS was ameliorated by PVP were similar to those in DYS patients who did not benefit from PVP. No significant differences in the rate or pattern of neuronal discharge in patients with DYS of different causes were discernible. PVP was most beneficial in patients with primary genetic DYS. Anesthesia with desflurane depressed the discharge rate of the GPe and GPi neurons, particularly in patients with PD. CONCLUSION: Significant differences in the rates and patterns of discharge of GPe and GPi neurons exist in DYS and PD. The findings are discussed with reference to the current model of the functional connections of the basal ganglia.

KW - Dystonia

KW - Electrophysiology

KW - Globus pallidus externa

KW - Globus pallidus interna

KW - Parkinson's disease

KW - Posteroventral pallidotomy

KW - Putamen

UR - http://www.scopus.com/inward/record.url?scp=0038278750&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038278750&partnerID=8YFLogxK

M3 - Article

C2 - 12762881

AN - SCOPUS:0038278750

VL - 52

SP - 1358

EP - 1373

JO - Neurosurgery

JF - Neurosurgery

SN - 0148-396X

IS - 6

ER -