Basal hippocampal activity and its functional connectivity predicts cocaine relapse

Bryon Adinoff, Hong Gu, Carmen Merrick, Meredith McHugh, Haekyung Jeon-Slaughter, Hanzhang Lu, Yihong Yang, Elliot A. Stein

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background Cocaine-induced neuroplastic changes may result in a heightened propensity for relapse. Using regional cerebral blood flow (rCBF) as a marker of basal neuronal activity, this study assessed alterations in rCBF and related resting state functional connectivity (rsFC) to prospectively predict relapse in patients following treatment for cocaine use disorder (CUD). Methods Pseudocontinuous arterial spin labeling functional magnetic resonance imaging and resting blood oxygen level-dependent functional magnetic resonance imaging data were acquired in the same scan session in abstinent participants with CUD before residential treatment discharge and in 20 healthy matched control subjects. Substance use was assessed twice weekly following discharge. Relapsed participants were defined as those who used stimulants within 30 days following treatment discharge (n = 22); early remission participants (n = 18) did not. Results Voxel-wise, whole-brain analysis revealed enhanced rCBF only in the left posterior hippocampus (pHp) in the relapsed group compared with the early remission and control groups. Using this pHp as a seed, increased rsFC strength with the posterior cingulate cortex (PCC)/precuneus was seen in the relapsed versus early remission subgroups. Together, both increased pHp rCBF and strengthened pHp-PCC rsFC predicted relapse with 75% accuracy at 30, 60, and 90 days following treatment. Conclusions In CUD participants at risk of early relapse, increased pHp basal activity and pHp-PCC circuit strength may reflect the propensity for heightened reactivity to cocaine cues and persistent cocaine-related ruminations. Mechanisms to mute hyperactivated brain regions and delink dysregulated neural circuits may prove useful to prevent relapse in patients with CUD.

Original languageEnglish (US)
Pages (from-to)496-504
Number of pages9
JournalBiological Psychiatry
Volume78
Issue number7
DOIs
StatePublished - Oct 1 2015

Fingerprint

Cocaine
Cerebrovascular Circulation
Hippocampus
Recurrence
Regional Blood Flow
Gyrus Cinguli
Magnetic Resonance Imaging
Residential Treatment
Parietal Lobe
Brain
Cues
Seeds
Therapeutics
Oxygen
Control Groups

Keywords

  • Cocaine dependence
  • Functional connectivity
  • Functional MRI
  • Hippocampus
  • Limbic system
  • Regional cerebral blood flow

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Adinoff, B., Gu, H., Merrick, C., McHugh, M., Jeon-Slaughter, H., Lu, H., ... Stein, E. A. (2015). Basal hippocampal activity and its functional connectivity predicts cocaine relapse. Biological Psychiatry, 78(7), 496-504. https://doi.org/10.1016/j.biopsych.2014.12.027

Basal hippocampal activity and its functional connectivity predicts cocaine relapse. / Adinoff, Bryon; Gu, Hong; Merrick, Carmen; McHugh, Meredith; Jeon-Slaughter, Haekyung; Lu, Hanzhang; Yang, Yihong; Stein, Elliot A.

In: Biological Psychiatry, Vol. 78, No. 7, 01.10.2015, p. 496-504.

Research output: Contribution to journalArticle

Adinoff, B, Gu, H, Merrick, C, McHugh, M, Jeon-Slaughter, H, Lu, H, Yang, Y & Stein, EA 2015, 'Basal hippocampal activity and its functional connectivity predicts cocaine relapse', Biological Psychiatry, vol. 78, no. 7, pp. 496-504. https://doi.org/10.1016/j.biopsych.2014.12.027
Adinoff, Bryon ; Gu, Hong ; Merrick, Carmen ; McHugh, Meredith ; Jeon-Slaughter, Haekyung ; Lu, Hanzhang ; Yang, Yihong ; Stein, Elliot A. / Basal hippocampal activity and its functional connectivity predicts cocaine relapse. In: Biological Psychiatry. 2015 ; Vol. 78, No. 7. pp. 496-504.
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AU - Yang, Yihong

AU - Stein, Elliot A.

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N2 - Background Cocaine-induced neuroplastic changes may result in a heightened propensity for relapse. Using regional cerebral blood flow (rCBF) as a marker of basal neuronal activity, this study assessed alterations in rCBF and related resting state functional connectivity (rsFC) to prospectively predict relapse in patients following treatment for cocaine use disorder (CUD). Methods Pseudocontinuous arterial spin labeling functional magnetic resonance imaging and resting blood oxygen level-dependent functional magnetic resonance imaging data were acquired in the same scan session in abstinent participants with CUD before residential treatment discharge and in 20 healthy matched control subjects. Substance use was assessed twice weekly following discharge. Relapsed participants were defined as those who used stimulants within 30 days following treatment discharge (n = 22); early remission participants (n = 18) did not. Results Voxel-wise, whole-brain analysis revealed enhanced rCBF only in the left posterior hippocampus (pHp) in the relapsed group compared with the early remission and control groups. Using this pHp as a seed, increased rsFC strength with the posterior cingulate cortex (PCC)/precuneus was seen in the relapsed versus early remission subgroups. Together, both increased pHp rCBF and strengthened pHp-PCC rsFC predicted relapse with 75% accuracy at 30, 60, and 90 days following treatment. Conclusions In CUD participants at risk of early relapse, increased pHp basal activity and pHp-PCC circuit strength may reflect the propensity for heightened reactivity to cocaine cues and persistent cocaine-related ruminations. Mechanisms to mute hyperactivated brain regions and delink dysregulated neural circuits may prove useful to prevent relapse in patients with CUD.

AB - Background Cocaine-induced neuroplastic changes may result in a heightened propensity for relapse. Using regional cerebral blood flow (rCBF) as a marker of basal neuronal activity, this study assessed alterations in rCBF and related resting state functional connectivity (rsFC) to prospectively predict relapse in patients following treatment for cocaine use disorder (CUD). Methods Pseudocontinuous arterial spin labeling functional magnetic resonance imaging and resting blood oxygen level-dependent functional magnetic resonance imaging data were acquired in the same scan session in abstinent participants with CUD before residential treatment discharge and in 20 healthy matched control subjects. Substance use was assessed twice weekly following discharge. Relapsed participants were defined as those who used stimulants within 30 days following treatment discharge (n = 22); early remission participants (n = 18) did not. Results Voxel-wise, whole-brain analysis revealed enhanced rCBF only in the left posterior hippocampus (pHp) in the relapsed group compared with the early remission and control groups. Using this pHp as a seed, increased rsFC strength with the posterior cingulate cortex (PCC)/precuneus was seen in the relapsed versus early remission subgroups. Together, both increased pHp rCBF and strengthened pHp-PCC rsFC predicted relapse with 75% accuracy at 30, 60, and 90 days following treatment. Conclusions In CUD participants at risk of early relapse, increased pHp basal activity and pHp-PCC circuit strength may reflect the propensity for heightened reactivity to cocaine cues and persistent cocaine-related ruminations. Mechanisms to mute hyperactivated brain regions and delink dysregulated neural circuits may prove useful to prevent relapse in patients with CUD.

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KW - Limbic system

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