Basic science review on adipose tissue for clinicians

Spencer A. Brown, Benjamin Levi, Charlotte Lequex, Victor W. Wong, Ali Mojallal, Michael T. Longaker

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations

Abstract

The recognition that fat contains stem cells has driven further examination into the potential uses of fat and adipose-derived stem cells in a wide number of clinical situations. New information about the harvesting, isolation, and subsequent differentiation properties of isolated adipose-derived stem cells has led to new research into novel tissue-engineered constructs and the transformation of adipose-derived stem cells to induced pluripotent stem cells. Clinically, use of fat grafts and adipose-derived stem cells worldwide and in the United States has dramatically increased in parallel to questions concerning the safety and efficacy of adipose-derived stem cell-based treatments. Currently, the U.S. Food and Drug Administration has not approved the use of isolated adipose-derived stem cells for medical indications.

Original languageEnglish (US)
Pages (from-to)1936-1946
Number of pages11
JournalPlastic and reconstructive surgery
Volume126
Issue number6
DOIs
StatePublished - Dec 2010

ASJC Scopus subject areas

  • Surgery

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