Beyond Dysplasia Grade: The Role of Biomarkers in Stratifying Risk

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Gastroenterology society guidelines recommend endoscopic surveillance as a means to detect early stage cancer in Barrett's esophagus. However, the incidence of esophageal adenocarcinoma in Western countries continues to increase, suggesting that this strategy may be inadequate. Current surveillance methods rely on the endoscopist's ability to identify suspicious areas of Barrett's esophagus to biopsy, random biopsies, and on the histopathologic diagnosis of dysplasia. This review highlights the challenges of using dysplasia to stratify cancer risk and addresses the development and use of molecular biomarkers and in vivo molecular imaging to detect early neoplasia in Barrett's esophagus.

Original languageEnglish (US)
Pages (from-to)447-459
Number of pages13
JournalGastrointestinal Endoscopy Clinics of North America
Volume27
Issue number3
DOIs
StatePublished - Jul 2017

Keywords

  • Barrett's esophagus
  • Biomarker
  • Confocal laser endomicroscopy
  • Dysplasia
  • Fluorescence endoscopy
  • In vivo imaging

ASJC Scopus subject areas

  • Gastroenterology

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