Beyond Molecular Codes: Simple Rules to Wire Complex Brains

Bassem A. Hassan, P. Robin Hiesinger

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Molecular codes, like postal zip codes, are generally considered a robust way to ensure the specificity of neuronal target selection. However, a code capable of unambiguously generating complex neural circuits is difficult to conceive. Here, we re-examine the notion of molecular codes in the light of developmental algorithms. We explore how molecules and mechanisms that have been considered part of a code may alternatively implement simple pattern formation rules sufficient to ensure wiring specificity in neural circuits. This analysis delineates a pattern-based framework for circuit construction that may contribute to our understanding of brain wiring.

Original languageEnglish (US)
Pages (from-to)285-291
Number of pages7
JournalCell
Volume163
Issue number2
DOIs
StatePublished - Oct 8 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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