bHLH factors in neurogenesis and neuronal subtype specification

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


The basic helix-loop-helix (bHLH) family of transcription factors plays essential roles in neurogenesis and neuronal subtype specification. Neural bHLH transcription factors fall into at least two major subclasses—those that induce neuronal differentiation and others that inhibit this process to maintain cells in a stem or progenitor state. In addition, some bHLH factors function in specifying distinct neuronal subtypes, generating the neuronal diversity seen in mature nervous systems. The focus of this chapter is on genetic and molecular mechanisms by which neural bHLH factors regulate progenitors as they undergo neuronal differentiation and neuronal subtype specification and how they themselves are regulated.

Original languageEnglish (US)
Title of host publicationPatterning and Cell Type Specification in the Developing CNS and PNS
Subtitle of host publicationComprehensive Developmental Neuroscience, Second Edition
Number of pages22
ISBN (Electronic)9780128144053
ISBN (Print)9780128144060
StatePublished - Jan 1 2020


  • Neurogenesis
  • Neuronal differentiation
  • Neuronal subtype specification
  • Notch signaling
  • Proneural bHLH
  • Transcription factor

ASJC Scopus subject areas

  • Neuroscience(all)


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