TY - JOUR
T1 - Bik and Bak induce apoptosis downstream of CrmA but upstream of inhibitor of apoptosis
AU - Orth, Kim
AU - Dixit, Vishva M.
PY - 1997/4/4
Y1 - 1997/4/4
N2 - Recent studies have identified a number of cell death pathway components. In this study, we describe the role that two such components, Bik and Bak, play in initiating the apoptotic program. These Bcl-2 family members engage the death pathway downstream of the block imposed by the serpin CrmA, but upstream of the block initiated by cellular inhibitors of apoptosis, which are a family of molecules characterized by a conserved baculovirus inhibitor of apoptosis repeat motif. Distal death pathway components activated by Bik and Bak are similar to those activated by the CD-95 (Fas/Apo1) and tumor necrosis factor death receptors.
AB - Recent studies have identified a number of cell death pathway components. In this study, we describe the role that two such components, Bik and Bak, play in initiating the apoptotic program. These Bcl-2 family members engage the death pathway downstream of the block imposed by the serpin CrmA, but upstream of the block initiated by cellular inhibitors of apoptosis, which are a family of molecules characterized by a conserved baculovirus inhibitor of apoptosis repeat motif. Distal death pathway components activated by Bik and Bak are similar to those activated by the CD-95 (Fas/Apo1) and tumor necrosis factor death receptors.
UR - http://www.scopus.com/inward/record.url?scp=0030910584&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030910584&partnerID=8YFLogxK
U2 - 10.1074/jbc.272.14.8841
DO - 10.1074/jbc.272.14.8841
M3 - Article
C2 - 9082997
AN - SCOPUS:0030910584
SN - 0021-9258
VL - 272
SP - 8841
EP - 8844
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 14
ER -