Bik and Bak induce apoptosis downstream of CrmA but upstream of inhibitor of apoptosis

Kim Orth, Vishva M. Dixit

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Recent studies have identified a number of cell death pathway components. In this study, we describe the role that two such components, Bik and Bak, play in initiating the apoptotic program. These Bcl-2 family members engage the death pathway downstream of the block imposed by the serpin CrmA, but upstream of the block initiated by cellular inhibitors of apoptosis, which are a family of molecules characterized by a conserved baculovirus inhibitor of apoptosis repeat motif. Distal death pathway components activated by Bik and Bak are similar to those activated by the CD-95 (Fas/Apo1) and tumor necrosis factor death receptors.

Original languageEnglish (US)
Pages (from-to)8841-8844
Number of pages4
JournalJournal of Biological Chemistry
Volume272
Issue number14
DOIs
StatePublished - Apr 4 1997

Fingerprint

Apoptosis
Serpins
Death Domain Receptors
Tumor Necrosis Factor Receptors
Baculoviridae
Cell death
Cell Death
Tumor Necrosis Factor-alpha
Molecules

ASJC Scopus subject areas

  • Biochemistry

Cite this

Bik and Bak induce apoptosis downstream of CrmA but upstream of inhibitor of apoptosis. / Orth, Kim; Dixit, Vishva M.

In: Journal of Biological Chemistry, Vol. 272, No. 14, 04.04.1997, p. 8841-8844.

Research output: Contribution to journalArticle

@article{1dac739630cc473984c301f9994c377a,
title = "Bik and Bak induce apoptosis downstream of CrmA but upstream of inhibitor of apoptosis",
abstract = "Recent studies have identified a number of cell death pathway components. In this study, we describe the role that two such components, Bik and Bak, play in initiating the apoptotic program. These Bcl-2 family members engage the death pathway downstream of the block imposed by the serpin CrmA, but upstream of the block initiated by cellular inhibitors of apoptosis, which are a family of molecules characterized by a conserved baculovirus inhibitor of apoptosis repeat motif. Distal death pathway components activated by Bik and Bak are similar to those activated by the CD-95 (Fas/Apo1) and tumor necrosis factor death receptors.",
author = "Kim Orth and Dixit, {Vishva M.}",
year = "1997",
month = "4",
day = "4",
doi = "10.1074/jbc.272.14.8841",
language = "English (US)",
volume = "272",
pages = "8841--8844",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "14",

}

TY - JOUR

T1 - Bik and Bak induce apoptosis downstream of CrmA but upstream of inhibitor of apoptosis

AU - Orth, Kim

AU - Dixit, Vishva M.

PY - 1997/4/4

Y1 - 1997/4/4

N2 - Recent studies have identified a number of cell death pathway components. In this study, we describe the role that two such components, Bik and Bak, play in initiating the apoptotic program. These Bcl-2 family members engage the death pathway downstream of the block imposed by the serpin CrmA, but upstream of the block initiated by cellular inhibitors of apoptosis, which are a family of molecules characterized by a conserved baculovirus inhibitor of apoptosis repeat motif. Distal death pathway components activated by Bik and Bak are similar to those activated by the CD-95 (Fas/Apo1) and tumor necrosis factor death receptors.

AB - Recent studies have identified a number of cell death pathway components. In this study, we describe the role that two such components, Bik and Bak, play in initiating the apoptotic program. These Bcl-2 family members engage the death pathway downstream of the block imposed by the serpin CrmA, but upstream of the block initiated by cellular inhibitors of apoptosis, which are a family of molecules characterized by a conserved baculovirus inhibitor of apoptosis repeat motif. Distal death pathway components activated by Bik and Bak are similar to those activated by the CD-95 (Fas/Apo1) and tumor necrosis factor death receptors.

UR - http://www.scopus.com/inward/record.url?scp=0030910584&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030910584&partnerID=8YFLogxK

U2 - 10.1074/jbc.272.14.8841

DO - 10.1074/jbc.272.14.8841

M3 - Article

C2 - 9082997

AN - SCOPUS:0030910584

VL - 272

SP - 8841

EP - 8844

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 14

ER -