TY - JOUR
T1 - Bio-nano interface
T2 - The impact of biological environment on nanomaterials and their delivery properties
AU - Cai, Kaimin
AU - Wang, Andrew Z.
AU - Yin, Lichen
AU - Cheng, Jianjun
N1 - Funding Information:
The authors acknowledge the financial support from the National Science Foundation (DMR-1309525 and CHE-1508710, for J.C.), and the National Natural Science Foundation of China (51403145 and 51573123) and Priority Academic Program Development of Jiangsu Higher Education Institutions (for L.Y.). K.C. acknowledges the support of Beckman Institute Graduate Fellowship at the University of Illinois at Urbana-Champaign, with funding provided by the Arnold and Mabel Beckman Foundation.
Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/10/10
Y1 - 2017/10/10
N2 - The past several decades have witnessed the rapid development of nanomedicine (NM) which integrates the advancement of various interdisciplinary areas of science, engineering, and medicine. While a few clinical successes of NM greatly change the landscape of disease diagnosis and treatment, there are several areas of NM remaining to be explored. One such area is the complicated interactions between the NM and biological environment post administration, and how such interaction affects the biological performance of NM. Here, we review the recent progresses on this topic and discuss the interaction of NM with microscopic biomolecules, cells, and the macroscopic in vivo environment. The complete profiling of the bio/nanomaterials interface and interaction should have profound impact on the optimization and de novo design of new NM with better in vivo performance.
AB - The past several decades have witnessed the rapid development of nanomedicine (NM) which integrates the advancement of various interdisciplinary areas of science, engineering, and medicine. While a few clinical successes of NM greatly change the landscape of disease diagnosis and treatment, there are several areas of NM remaining to be explored. One such area is the complicated interactions between the NM and biological environment post administration, and how such interaction affects the biological performance of NM. Here, we review the recent progresses on this topic and discuss the interaction of NM with microscopic biomolecules, cells, and the macroscopic in vivo environment. The complete profiling of the bio/nanomaterials interface and interaction should have profound impact on the optimization and de novo design of new NM with better in vivo performance.
KW - Cell-mediated delivery
KW - Drug delivery
KW - Intracellular delivery
KW - Nanomedicine
KW - Protein corona
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U2 - 10.1016/j.jconrel.2016.11.034
DO - 10.1016/j.jconrel.2016.11.034
M3 - Review article
C2 - 28062299
AN - SCOPUS:85013412150
SN - 0168-3659
VL - 263
SP - 211
EP - 222
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -