Bioerosion of Synthetic Sling Explants

Katherine E. Washington, Gina Quiram, Angela Nguyen, Ruvanthi N. Kularatne, Majid Minary-Jolandan, Philippe Zimmern, Mihaela C. Stefan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This study was performed to investigate the changes over time in polypropylene (PP) mesh explants from women with stress urinary incontinence originally treated with a midurethral PP sling. Following Institutional Review Board (IRB) approval, 10 PP explants removed for pain or obstructive symptoms between January and June 2016 were analyzed through various techniques to determine the degradation of the material in vivo. Exclusion criteria were exposed or infected mesh sling or sling in place for less than six months. One pristine control was studied for comparison. The explant samples were analyzed with scanning electron microscopy to visualize the surface defects as well as infrared spectroscopy and energy dispersive X-ray spectroscopy to determine if the degradation was oxidative in nature. The results show qualitative and quantitative bioerosion over the surface of the explant samples and an increase in the content of oxygen pointing toward oxidative degradation occurring in vivo.

Original languageEnglish (US)
Pages (from-to)2598-2605
Number of pages8
JournalACS Biomaterials Science and Engineering
Volume3
Issue number10
DOIs
StatePublished - Oct 9 2017

Fingerprint

Slings
Polypropylenes
Degradation
Surface defects
Infrared spectroscopy
Oxygen
Scanning electron microscopy

Keywords

  • oxidative degradation
  • polypropylene
  • sling mesh explant
  • surgical mesh
  • synthetic sling

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

Cite this

Washington, K. E., Quiram, G., Nguyen, A., Kularatne, R. N., Minary-Jolandan, M., Zimmern, P., & Stefan, M. C. (2017). Bioerosion of Synthetic Sling Explants. ACS Biomaterials Science and Engineering, 3(10), 2598-2605. https://doi.org/10.1021/acsbiomaterials.7b00614

Bioerosion of Synthetic Sling Explants. / Washington, Katherine E.; Quiram, Gina; Nguyen, Angela; Kularatne, Ruvanthi N.; Minary-Jolandan, Majid; Zimmern, Philippe; Stefan, Mihaela C.

In: ACS Biomaterials Science and Engineering, Vol. 3, No. 10, 09.10.2017, p. 2598-2605.

Research output: Contribution to journalArticle

Washington, KE, Quiram, G, Nguyen, A, Kularatne, RN, Minary-Jolandan, M, Zimmern, P & Stefan, MC 2017, 'Bioerosion of Synthetic Sling Explants', ACS Biomaterials Science and Engineering, vol. 3, no. 10, pp. 2598-2605. https://doi.org/10.1021/acsbiomaterials.7b00614
Washington KE, Quiram G, Nguyen A, Kularatne RN, Minary-Jolandan M, Zimmern P et al. Bioerosion of Synthetic Sling Explants. ACS Biomaterials Science and Engineering. 2017 Oct 9;3(10):2598-2605. https://doi.org/10.1021/acsbiomaterials.7b00614
Washington, Katherine E. ; Quiram, Gina ; Nguyen, Angela ; Kularatne, Ruvanthi N. ; Minary-Jolandan, Majid ; Zimmern, Philippe ; Stefan, Mihaela C. / Bioerosion of Synthetic Sling Explants. In: ACS Biomaterials Science and Engineering. 2017 ; Vol. 3, No. 10. pp. 2598-2605.
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