Biofunctionalized targeted nanoparticles for therapeutic applications

Andrew Z. Wang, Frank Gu, Liangfang Zhang, Juliana M. Chan, Aleksander Radovic-Moreno, Mariam R. Shaikh, Omid C. Farokhzad

Research output: Contribution to journalReview articlepeer-review

193 Scopus citations

Abstract

Background: The development of nanoparticles for the delivery of therapeutic agents has introduced new opportunities for the improvement of medical treatment. Recent efforts have focused on developing targeted nanoparticles, which are formulated by (for therapeutic delivery) functionalizing nanoparticle surfaces with targeting molecules, such as antibodies, peptides, small molecules and oligonucleotides. Objectives: To review the state of targeted nanoparticles development. Methods: The authors discuss the nanoparticle platforms for therapeutic delivery, targeting molecules and the biofunctionalized targeted nanoparticles currently in development. Results/conclusions: Biofunctionalized targeted nanoparticles have demonstrated exciting results in preclinical studies. With continued improvements, they may fulfill their potential as therapeutics carriers that can deliver the maximum dose to diseased tissue while minimizing effects on normal cells.

Original languageEnglish (US)
Pages (from-to)1063-1070
Number of pages8
JournalExpert Opinion on Biological Therapy
Volume8
Issue number8
DOIs
StatePublished - Aug 2008
Externally publishedYes

Keywords

  • Biofunctionalized
  • Nanoparticle
  • Targeted nanoparticles
  • Targeting
  • Therapeutics delivery

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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